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by
Y. Unal |
Total Records (
2 ) for
Y. Unal |
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M. Cenesiz
,
S. Yildiz
,
M. Kaya
,
F. Onder
,
O. Ucar
,
M. Uzun
,
M. Blackberry
,
D. Blache
,
I. Kaya
,
Y. Unal
,
A. Oncuer
and
G.B. Martin
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im of the current study, was to evaluate the effects of diets containing different levels of tanniniferous oak (Quercus hartwissiana) leaves in the absence and presence of a tannin binding substance, polyethylene glycol, on plasma leptin, IGF-I and LH levels in ewe-lambs. Lambs (n = 42) were kept in individual metabolism cages and a total of 7 groups (n = 6 per group) were formed (Group I, control; Group II, 185 g leaf; Group III, 370 g leaf; Group IV, 185 g leaf plus 10 g PEG; Group V, 185 g leaf plus 20 g PEG; Group VI, 370 g leaf plus 20 g PEG; Group VII as 370 g leaf plus 40 g PEG). All groups were given 272 g concentrate and varying amounts of hay in a way that the amount of roughage was equal to 645 g. The diets were isonitrogenous and isoenergetical and the experiment continued for 60 days. Blood samples were collected fortnightly for the measurement of leptin and IFG-I. Additionally, on day 55 post-prandial rhythm of leptin was assessed with 30 min intervals for 8 h and LH response to naloxone was assessed for 2 h with 15 min intervals. For the determination of LH pulsatility, blood samples were collected on day 45 of the experiment with 15 min intervals for 6 h. IGF-I levels, fortnigtly leptin secretion, LH pulsatility and LH response to naloxone did not differ among the groups. Post-prandial leptin secretion appeared to be episodic but it was not affected by dietary treatments (p>0.05). Both leptin and IGF-I concentrations were positively correlated to LH pulse frequency (R2 = 0.235, p = 0.027 and R2 = 0.248, p = 0.006, respectively). In conclusion, the results suggest that tanniniferous Q. hartwissiana leaves do not have any effect on leptin, IGF-I and LH secretion and that leptin secretion appears to be in episodic manner and that leptin and IGF-I secretions appear to signal reproductive axis in ewe-lambs. |
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Y. Unal
,
O. Ozsoylar
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D. Sariguney
,
D. Sariguney
,
M. Arslan
and
R.S. Yardim
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In this study, we aimed to determine the efficacy of esmolol infusion to prevent the hyperdynamic state which occurs during the recovery period and after extubation in the patients having lumbar disc surgery under general anesthesia. Forty five patients who would undergo elective lumbar disc surgery were randomly divided into three groups and general anesthesia was induced with 5-7 mg kg 1 sodiumthiopental and 0.5 mg kg 1 atracurium; it was maintained with isoflurane in 50/50 % oxygen-air mixture and 0.1-0.3 µg kg 1 min 1 remifentanil infusion. On the completion of the surgery both of the goups (Group E1 and GroupE2) received esmolol 0.5 mg kg 1 as a loading dose. Following the 4 min infusion, Group E1 patients were administered 0.1 mg kg 1 min 1 esmolol while GroupE2 patients received 0.2 mg kg 1 min 1 esmolol infusion and it continued till 10 min after extubation. The control group (Group C) patients received the same dose of saline infusion for the same duration. Heart rate was significantly higher in control group than those in groups E1 and E2 at 5th and 10th min of esmolol infusion. Also mean arterial pressure was higher in the control group than those in groups E1 and E2 at 5th and 10th min during esmolol infusion and 10 min after extubation (p< 0.05). The time for opening eyes in response to verbal commands was shorter in both esmolol groups compared to the control group(p< 0.05). The time for opening eyes spontaneously in Group E2 was shorter than it was in the control group(p< 0.05) whereas there was no difference in Group E1. Five patients in the control group (33.3%) needed antihypertensive agents while there was no need for such additional agents in GroupE1 and GroupE2. We think that both dose profiles can be used to prevent hyperdynamic state which occur during extubation without extending the recovery period, which will lead to an early postoperative clinical assessment. |
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