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by
Y. Saidu |
Total Records (
3 ) for
Y. Saidu |
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M.T. Adewumi
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C.H. Njoku
,
Y. Saidu
,
M.K. Abubakar
,
R.A. Shehu
and
L.S. Bilbis
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In this study serum copper, chromium and manganese were estimated in 90 diabetic patients attending the outpatient clinic of the Federal Medical Centre, Katsina, an ancient city in North-western Nigeria and the results compared to those of apparently healthy, non-diabetic volunteers of comparable age and social status. Serum glucose level of the diabetic subjects (13.91±2.87 mmol L-1) was significantly (p<0.05) higher that the value obtained for the non-diabetic subjects (4.34±0.11 mmol L-1). The serum levels of Cr (0.19±0.05 μg L-1), Cu (0.42±0.18 μg L-1) and Mn ((1.12±0.24 μg L-1) were significantly (p<0.05) lowered in diabetic subjects. About 75% of the diabetic subjects in the study area had deficient serum levels of these metals. These results suggest that the diabetic patients in the study area have low serum levels of some antioxidant mineral elements. These observations may be an indication that the diabetic subjects are predisposed to increased oxidative onslaught. |
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Y. Saidu
,
L.S. Bilbis
,
M. Lawal
,
S.A. Isezuo
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S.W. Hassan
and
A.Y. Abbas
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The current study reports the toxicological studies of the crude aqueous leaf extract using albino rat models. The in vivo effects of acute and sub-chronic doses of the extract on liver function and kidney function parameters were studied. The results indicated that the LD50 of the extract is > 3000 mg kg-1 body weight. There were no significant differences (p>0.05) in weight changes of the animals on different doses of the extract during both the acute and sub-chronic toxicity tests. The biochemical parameters of the animals on different doses of the extract were not significantly (p>0.05) different, except the ALT and AST that, in non-dose dependence, showed significant differences (p<0.05) in both test models. Serum globulin level of the animals on different doses during the sub-chronic test was also significantly different (p<0.05). These results indicated that the crude extract of A. chevalieri may be relatively safe for human consumption. |
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S.W. Hassan
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F.L. Bilbis
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M.J. Ladan
,
R.A. Umar
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S.M.Dangoggo
,
Y. Saidu
,
M.K. Abubakar
and
U.Z. Faruk
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The aqueous and organic solvents extracts of leaves, stem barks and roots of Calotropis procera were screened for antifungal (agar dilution method) and phytochemical properties. Organic solvents extracts of the stem bark significantly (p<0.05) inhibited growth of Trichophyton rubrum and Microsporum gypseum. The petroleum ether (PE) extract however was significantly (p<0.05) active on only Trichophyton rubrum at concentrations ranging from 0.66 to 5.33 mg mL-1. All the leave extract fractions completely inhibited the growth of the tested organisms. The roots fractions of hexane (HX) and PE extracts showed significant (p<0.05) growth inhibitions of Microsporum gypseum and Aspergillus niger. All the aqueous extract fractions of the plant parts showed complete growth inhibition of all the tested organisms. Alkaloids, flavonoids, tannins, steroids, triterpenoids, saponins and saponin glycosides were detected in the leaves and roots extract fractions, with only flavonoids, triterpenoids and saponins in the stem bark extracts. The results obtained lend scientific credence for the use of the plant against fungal diseases. |
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