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Articles by Wagner Ferreira dos Santos
Total Records ( 3 ) for Wagner Ferreira dos Santos
  Renato Guizzo , Marcelo Araujo Rodrigues Cairrao , Joaquim Coutinho-Netto , Antonio Renato Meirelles e Silva , Norberto Cysne Coimbra and Wagner Ferreira dos Santos
  We compared qualitative and quantitatively the neuroprotective effects of ketamine, nimodipine and lamotrigine in rat retinas submitted to acute ischemia and ischemia followed by reperfusion. Ischemia was induced by increasing of intraocular pressure above systolic blood pressure for 60 min. In reperfusion, intraocular pressure was reduced to normal levels for 45 min. Histological evaluation was performed by computer-assisted measurements from histologic sections. Ischemic retinas revealed a decrease in cells densities, cytoplasm vacuolization, pyknotic nuclei, edema and cell disorganization, when compared to contralateral-control eyes. Further, ischemia/reperfusion showed more evident retinal damage when compared to ischemic retinas. Lamotrigine pretreatment (25 mg kg-1) protected neurons mainly in ganglinar cell layer. Nimodipine pretreatment (20 μg kg-1) protected neurons of ganglion cell layer in ischemia and in ischemia/reperfusion the inner nuclear layer. Ketamine pretreatment (20 mg kg-1) protected neurons mainly in outer nuclear layer and inner nuclear layer in ischemia and ischemia/reperfusion. Present results suggest that lamotrigine, nimodipine and ketamine have potential neuroprotective properties in acute ischemia and ischemia/reperfusion models and all of them may have therapeutic implications for retina.
  Márcia Renata Mortari , Alexandra Olimpio Siqueira Cunha , Luciana de Oliveira , Erica Aparecida Gelfuso , Eveline Bis Vieira and Wagner Ferreira dos Santos
  In this study we have investigated hemolytic, edematogenic and neurotoxic effects of the crude venoms of three Polybia species; P. occidentalis, P. paulista and P. ignobilis. In addition, protein contents and dry weights of these wasp`s venom reservoirs have also been compared. P. ignobilis presented the highest protein content and highest dry weight per venom reservoir. When injected in the hind paw of rats relatively to the other two, it evoked a stronger edematogenic effect. The venom of P. paulista showed the most potent hemolytic activity on human washed red blood cells. When tested on the erythrocytes of different species (rat, pigeon, ox, sheep, snake and horse), the three venoms showed marked differences in hemolytic activity according to the blood species. However, this variability appeared to be similar for the three venoms. Moreover, the intracerebroventricular injection of each of all three venoms caused tonic clonic seizures and death to rats. Present data suggest that although the three species are closely phylogenetic related, there must be pharmacological differences among the venom compounds that should be better investigated.
  Ruither Oliveira Gomes Carolino , Alessandra Lourenço Cecchini , Renê Oliveira Beleboni , Ricardo Guelerman Pinheiro Ramos , Joaquim Coutinho-Netto and Wagner Ferreira dos Santos
  In this study, we show the toxic effect of A. carambola Aqueous Extract (AcAE) on Drosophila melanogaster life cycle and its paralyzing effect on termites (Sintermes grandis). In our assays, AcAE, at concentrations of 0.5, 5, 50 and 500 µg of protein/mL, caused a dose-dependent decrease of, respectively 28±1.96, 55±3.85, 73±5.11 and 91±6.67% of adult emergence from D. melanogaster pupae. After 180 min following application, the same series of concentrations produced a significant and irreversible dose-dependent paralysis of termites. This study presents the first description of star fruit insecticidal activity and the relevance of the toxic effect and/or growth development retarding effects of AcAE could acquire greater significance once observed following application in natural habitats.
 
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