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Articles by R.M. Al-Ashban
Total Records ( 5 ) for R.M. Al-Ashban
  K.E. Ibrahim , R.M. Al-Ashban and S.A. El-Sammani
  Detailed studies on the toxicity of cat’s claw capsules were carried out in mice through examination of possible biochemical, hematological and histopathological changes. Acute, subacute and chronic toxicity studies were undertaken by treating mice with a single dose of 150 mg kg-1 body weight for acute, 50 mg kg-1 body weight administered orally each other day for 7 days for subacute and an oral dose of 10 mg kg-1 body weight of the drug daily for 90 days for chronic toxicity studies. Hematological studies revealed a significant reduction in WBC levels (p<0.05) upon acute treatment of male and female mice as compared to the control. Biochemical studies showed significant rise in the levels of AST and ALT in acute and subacute treated mice. Hematological studies on the chronically treated male and female mice revealed no appreciable differences as compared to the control, except for a mild increase in platelet count. Biochemical studies revealed a non-significant increase in AST and ALT in the male group. Changes in key hepatic enzymes levels including aspartate aminotransferase, alanine-aminotransferase, alkaline phosphatase, enzyme MB of creatinine kinase, glucose, urea and creatinine and histopathological modifications (heart, liver, kidneys and pancreas) were not observed in mice treated with cat’s claw capsules. The low toxicity of cat’s claw as evidenced by key hepatic enzymes stability and organ integrity suggests a wide margin of safety for therapeutic doses of cat’s claw.
  I.A. Al-Omar , R.M. Al-Ashban and A.H. Shah
  Pulmonary Tuberculosis (PTB) is a common disease in developing countries and efforts have been made to diagnose patients presenting complex hematological and biochemical picture. Hematological abnormalities have been associated with tuberculosis and response to drug therapy often showed varied resistance. However, changes in response to therapy have not fully been determined in PTB patients living in the developing countries. In PTB patients rise in hemogloin and hematocrit levels are used as markers reflecting response to treatment. Furthermore, decrease in platelet count and in white cell count and reduction in Erythrocyte Sedimentation Rate (ESR) were regarded as good indicatiors to obverve drug responce and disease control. During current study mild anemia was frequently observed in PTB patients. Several reports suggested leucocytosis with neutrophilia. Platelet count and erythrocyte sedimentation rate were elevated in PTB which is well influenced and corrected by using different combinations of antituberculosis drugs. Although several investigations have been done on adult male and female PTB parients in Saudi Arabia, however, there is no comprehenssive report available on the significance of different haematological parameters in pretreatment and post-treatment PTB patients. Current study was designed to investigate hematological changes both in adult male and female Saudi PTB patients. All the parameters at the time of diagnosis and 6 weeks post-treatment were studied and the results are present in current communication.
  K.E. Ibrahim , R.M. Al-Ashban and S.A. El-Sammani
  Toxicity studies on Devil's claw capsules were conducted using mice by investigating the possible biochemical, hematological and histopathological changes. Acute, subacute and chronic toxicity studies were undertaken by treating mice with a single dose of (81 mg kg-1) body weight for acute (27 mg kg-1) body weight administered orally each other day for 7 days for subacute and an oral dose of (5.4 mg/kg/day) body weight of the drug daily for 90 days for chronic toxicity studies. Devil’s claw treated animals did not show any sign of toxicity and none of the animals died during the observation period. Hematological and biochemical studies showed non significant differences among the animals in the treatment groups and control groups.
  E.A. Gadkariem , R.M. Al-Ashban , L.B. Babikir and H.I. Al-Joher
  The toxicity studies of Korean ginseng capsules were evaluated in mice through examination of possible biochemical, hematological and histopathological changes. Acute, sub-acute and chronic toxicity studies were undertaken by treating mice with a single dose of 300 mg kg-1 body weight for acute, 100 mg kg-1 body weight administered orally each other day for 7 days for sub-acute and an oral dose of 20 mg kg-1 body weight of the drug daily for 90 days for chronic toxicity studies. In acute, sub-acute and chronic treated mice, biochemical studies revealed a significant decrease in the blood glucose level in all treated animals. Hematological studies revealed an increase in RBC and hemoglobin contents in the treated male group as compared to the control. Absent of signs of visceral toxicity and histopathology result confirmed that all the studied organs were normal compared to the control.
  E.A. Gadkariem , R.M. Al-Ashban , L.B. Babikir and H.I. AL-Johar
  The acute, sub-acute and chronic toxicity were conducted on Victoria 1500 and 2000 capsules which contains royal jelly, panax ginseng and yohimbe park, all individually have not shown any toxicity on long term administration. Study was planned to assess the safety of the combination by doing toxicity studies. Toxicity studies were done in two animal models by using mice and rats. Acute, sub-acute and chronic toxicity studies were undertaken by treating nimals with a single dose of 15 times the recommended dose for acute, 5 times recommended dose administered orally each other day for 7 days for sub-acute and a daily recommended dose for 6 months for chronic toxicity studies. In acute and sub-acute toxicity studies histopathological results confirmed all vital organs to be normal. The results of the biochemical and hematological studies revealed some changes in some parameters of the treated animals. In sub-acute an increase in RBC and hemoglobin levels was shown. Treatment showed no spermatotoxic activity. During chronic toxicity study, the visceral condition of the animals and histopathological investigations were found to be normal. There were no drastic changes in the biochemical and hematological parameters and the results of the sperm count, sperm motility and sperm viability, respectively were found to be: ≥14x106 mL-1, ≥50 and ≥50%.
 
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