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Articles by Omid Mashrabi
Total Records ( 15 ) for Omid Mashrabi
  Firozeh Akbari-Asbagh , Ebrahim Mostafavi , Kobra Hamdi , Ozra Azmodeh , Azizeh Ghasemynejad , Jinus Moshtaghi , Naser Salsabili and Omid Mashrabi
  Problem statement: Oxidative Stress (OS) has been recognized as one of the most important cause of male infertility. We studied the relation of serum and Semen Malondialdehyde (MDA) and Total Antioxidant Capacity (TAC) with sperm parameters in infertile men with sperm count within the normal range. Approach: The prospective case- control study performed on infertile men presenting to the infertility clinics of Mirzakochak khan hospital, Tehran university of Medical Sciences from June 2007 to June 2009. The samples were collected consecutively and the total of 40 infertile men was enrolled in the study. Also, 40 healthy men were matched as control group. MDA and TAC in serum and seminal plasma were measured and relation between them and semen analysis parameters were evaluated. The MDA was measured as nmol mL-1 and the TAC was expressed as g dL-1. Results: Analysis showed that the amount of semen MDA was statistically different in infertile and healthy control groups. We did not find any significant relation between smoking and sperm parameters in infertile men. The relation between semen MDA and abnormal sperm abnormal morphology (p = 0.003, r = -0.468) and semen TAC and weak sperm motility (p = 0.037, r = -0.359) was significant. Conclusion: Immediate attention should be directed at simplifying and validating the evaluation of reactive oxygen species and OS status so that it can be performed routinely.
  Mojtaba Varshochi , Mehdi Haghdoost and Omid Mashrabi
  Problem statement: Granulomatous Lobular Mastitis (GLM) or autoimmune mastitis is a rare and benign disease which, except one case reported in an old man, is usually seen during pregnancy or lactation period. This disease was described for the first time by Kessler. Approach: Our case is a 34 year-old woman who has a child with a history of using OCP that primary complaint was swelling, heat and erythema in the right breast. She was diagnosed with mastitis and treated with antibiotics for one month, later on she had experienced stiffness in the breast and a mass was also palpable. The patient was performed surgical drainage and treated with wide spectrum antibiotics being diagnosed with abscess. After one month, a solid mass was palpable so, mammography was performed and the mass was surgically resected with a suspicion of tumor. Results: The pathology report revealed granulomatous mastitis with non caseified granuloma. For Anti-TB treatment was started as medication regime and after 40 days fistula with frequent secretions appeared. Anti-tuberculosis medications stopped and other conditions resulting in none caseified granuloma. In microscopic view granulomatous mastitis along with abscess was reported. Corticosteroids were started and the mass became smaller gradually, the fistula also closed and secretions dried out. Conclusion: Granulomatous Lobular Mastitis is a benign inflammatory breast disease. Cause of disease is still unknown, but some factors have been suggested such as local autoimmune, reaction to the delivery, previous use of contraceptives and infectious causes. The best treatment proposed is corticosteroid therapy in which the mass dwindle and the fistula is closed and secretions dried. The case is now under treatment with corticosteroids and all her symptoms have improved.
  Abolfazl Poorhasan , Mehdi Haghdoost and Omid Mashrabi
  Problem statement: After HIV infection, TB is the most common cause of mortality due to a single infectious agent. Until 1985, tuberculosis cases in the world were decreasing every year, but then with the prevalence of HIV infection, TB cases are increasing every year. Obviously, with this prevalence of tuberculosis, the best way to control it is to track the patient and identify the people with latent TB and treat them. One third of the world population is infected with latent tuberculosis micro bacterium and tuberculosis causes two million deaths a year. Identification of people with latent TB infection is the primary aim to eradicate TB in the community. The method to measure gamma interferon in the blood called QuantiFERON®-TB Test is a promising diagnostic test for diagnosing latent TB infection and is more beneficent than compared to PPD. The aim of this study is to compare IFN-δ test and PPD test in diagnosis of patients with latent TB. Approach: In a cross-sectional descriptive-analytic study on 76 patients referred to the clinic or infectious diseases ward of Imam Reza or Sina hospitals or Tabriz University of Medical Sciences during 2007 and 2008, the patients whose CXR had fibrotic images or calcification compatible with latent TB infection were included in the study and the correlations between IFN-δ and PPD tests was evaluated. Results: Mean age of the patients in this study was 64.96±4.54 years with minimum 43 and maximum 81 of age. About 33.3% of people under study had a positive PPD test and 4% of the patients had a positive IFN-δ and the correlation coefficient between IFN-δ test and PPD test was estimated at 0.376 (p<01/0). Age and gender had no effect on positivity of the results of PPD test and IFN-δ tests. Conclusion: Capability of IFN-δ test in diagnosis of latent tuberculosis infection is comparable to that of PPD test; however, the correlation coefficient between the two tests was low and also, unlike other studies, gender and age had no effect on positivity or negativity of PPD and IFN-δ tests.
  Mehdi Haghdoost , Abolfazl Poorhasan , Kamyar Ghabili and Omid Mashrabi
  Problem statement: Injection of metallic mercury in the forms of subcutaneous or intravenous has been hitherto reported in less than a hundred cases. Approach: We reported a 19 year old male with history of major depression who subcutaneously injected metallic mercury into his right forearm with suicidal intention. Results: A week later, a mild elevation of creatinine level was noted. Subsequently, mercury deposits were totally removed with all affected tissues and fascia of the right forearm. Later, the creatinine level decreased to the normal range. Conclusion: The present case is an example of suicidal attempt that presented with subcutaneous injection of elemental mercury mimicking bacterial cellulitis. Physicians should consider heavy metal injections when evaluating a patient with history of psychiatric disorders presented with bacterial cellulitis.
  Zhinous Bayat Makoo , Nagmeh Ahadi , Akbar Hasani , Roshanak Bayat Makoo and Omid Mashrabi
  Problem statement: Bacterial meningitis is one of the most important causes of mortality and morbidity. Rapid diagnosis of bacterial cause is very important and critical, because early antibiotic therapy prevents complications; different tests have been developed for rapid diagnosis of bacterial meningitis. One of them is CSF ferritin, which is evaluated in this study. Approach: During cross sectional study from 2008-2009 for 2 years, CSF was collects from 61 adults suspected to have meningitis. These patients admitted to Emam Reza and Sina hospitals of Tabriz. CSF was analyzed for ferritin, glucose, protein, cell count, culture and gram stains. Clinical data’s were collected for all patients. Collected data’s were analyzed by SPSS software. Results: From 61 specimens, 19 cases had bacterial, 19 cases had aseptic meningitis and 23 cases had no criteria for diagnosis of meningitis. CSF ferritin in bacterial meningitis was 231.63 ± 61.26 ng dL-1 that was significantly higher, than that of aseptic meningitis group. Cut off value for ferritin was estimated 155ng dL-1 with sensitivity of 94% and specificity of 21.7% in this study. Symptoms such as levels of consciousness, fever and seizure were not considered as a criteria for diagnosis of bacterial meningitis (p>0.05). But symptoms such as headache, nausa, vomiting and neck stefness were significantly higher in bacterial and aseptic groups than no meningitis group (p<0.05). Conclusion: In this study CSF ferritin in bacterial meningitis group was significantly higher than aseptic meningitis group. But due to low specificity of CSF ferritin for differentiation of bacterial from aseptic meningitis, we don’t recommend performance of this test in early phase of meningitis course.
  Zhinous Bayat Makoo , Hamid Reza Soltani , Akbar Hasani , Roshanak Bayat Makoo and Omid Mashrabi
  Problem statement: Acute bacterial meningitis is one of the most important causes of medical emergency diseases, which can cause high mortality and morbidity rates. Early antibiotic therapy is life saving in bacterial meningitis. One of the most common etiologies of acute meningitis is viral. Differentiation between bacterial and Aseptic meningitis is mandatory, which leads to avoid useless administration of antibiotics. Various diagnostic tests are available for diagnosis of acute bacterial meningitis; one of these tests is serum procalcitonin. Approach: This survey is a descriptive cross-sectional study. During a 2 year period 50 patients over 13 years old who were admitted to Sina and Emam Reza hospitals of Tabriz University of Medical Sciences with presumptive diagnosis of acute meningitis were selected. Serum and Cerebrospinal Fluid (CSF) procalcitonin of the patients were measured by semiquantative chromatographic PCT-Q Assay. Statistical data’s of the patients were analyzed by SPSS 15. Results: 38% of the patients had acute bacterial and 62% aseptic meningitis, on the basis of positive clinical and lab tests. 0.5ng mL-1 of serum pricalcitonin was cut off point, which correlated to sensitivity of 100%, positive predictive value of 82.6%, specificity of 87.09% and negative predictive value of 100%. CSF procalcitonin cut off of 0.5ng mL-1 had sensitivity of 100% specificity of 84.21%, positive predictive value of 88.88% and negative predictive value of 90.62%. Conclusion: Serum procalcitonin cut off of 0.5 ng mL-1 has sensitivity and negative predictive value of 100%. This test can be a valuable measure in screening and differentiation of bacterial from aseptic meningitis.
  Zhinous Bayat Makoo , Roshanak Bayat Makoo and Omid Mashrabi
  Problem statement: During the last years it is more than evident that the prevalence of pulmonary and extrapulmonary Tuberculosis (TB), mainly in western European countries, has risen significantly. The aetiology of this phenomenon is multifactorial. Miliary tuberculosis is a form of tuberculosis that is characterized by millet-like seeding of TB bacilli in the lung, as evidenced on chest radiography. Approach: A 17-year-old woman with headache, nausea-vomiting and fever of two months before. The patient’s symptoms exacerbate and had weight that referred to the emergency department with severe headache and frequently vomiting. Bilateral coarse ceracel without wheezing. In primary CXR, diffuse reticulonodular two lungs with opened with pleural open angles. In thoracic HRCT images, diffuse micronodular lesions in throughout the lung Parenchyma, peribronchovascular thickening in parahilar areas and significant increases in the thickness of several upper lobe bronchus. Listen Read phonetically In brain MRI, multiple micronodular lesions with probably miliary TB were reported. AFB of BAL sample was 1+ and cytology of BAL was negative for malignancy. HIV Ab, HBS Ag, HCV Ab and IgM HAV were negative. U/A, U/C B/C was normal. Listen Read phonetically Conclusion: Results of BAL culture were positive for TB and Granulomatous inflammation, surrounded by mile lymphocytic infiltrate, with central necrosis, suggestive of TB were reported in endobronchial biopsy.
  Zinat Miabi and Omid Mashrabi
  Tumors of the Central Nervous System (CNS), occur relatively frequently during the early years of life. They are the most common solid tumors of childhood and are second only to leukemia in overall cancer incidence and account for a high proportion of deaths. In different studied, performed in several countries, astrocytomas and other gliomas (combined) accounted for half of the CNS malignancies, followed by PNET/MB and ependymomas and then craniopharyngioma. We have undertaken a perspective study with 349 brain tumor patients, ranging from 0-14 years of age, throughout a 5 years period (1998-2003). Who were admitted in Tabriz Koodakan Hospital or were diagnosed in Tabriz Hafez CT scan center, during radiological evolutions by CT. Craniopharyngioma was the most common type of tumors among patients studied in the series and astriocytomas was second and medulloblastoma was third common type. The male/female proportion of patients in total brain tumors according to the results is 1.56 and it is similar to earlier studies. About medulloblastoma and ependymomas, male/female proportion of patients in study is <1 (0.88, 0.7), but in earlier series it seems to be >1 (about 1.4). Age-related distribution of brain tumors in children under the age 14 was similar to that of other series to some extent. Also, since the causes and risk factors of CNS cancers remain largely undetermined, we could not reach a significant relationship between the tumors and location of life of patients. Hope that the results make a useful for the future studies in this field and differences obtained in this study with results of other series can help us more and more in management and treatment strategies if brain tumors in children of the population.
  Zinat Miabi and Omid Mashrabi
  Determining normal ranges of spinal canal diameters, we can make initial diagnosis in persons who have lower diameters of spinal canal. These persons are predisposed to spinal canal stenosis that is a major cause of spinal radiculopathies. In different studies performed in several countries, minimum and maximum ranges of spinal canal diameters were different for each population. In this study, we tried to determine the mean values of normal spinal canal diameters and areas ┬áin Tabriz and its suburb. Thirty nine healthy, young to mid-age cases were selected. Our study was focused on L3-L4 and L4-L5. The following parameters were measured: the area of cross-section of the vertebral body, the area of cross-section of the dural sac, interarticular diameter, interligamentous diameter, antero-posterior diameter of the lumbar canal, inter-pedicular diameter and the area of cross-section of the vertebral canal. A correlation between the parameters studied and the height of subjects was significant for interligamentous diameter (for L3/L4 and L4/L5) and interarticular diameter (only at L3/L4), cross-section area of the vertebrae (both L3 and L4), cross-section area of vertebral canal (only at L5 level), area of dural sac (at L3/L4 and L4). It was suggested that these diameters and areas should be interpreted as unction of height of the subject. Most of diameters studied had smaller means than those in previous studies. This can be attributed to differences between populations and it can be interpreted as predisposition to spinal canal stenosis in our population.
  Babak Vahdatpour , Saied Khosravi , Alireza Rahimi , Soheil Sattari , Alireza Mogtaderi , Farnaz Dabiri Scoie and Omid Mashrabi
  Work Related Musculoskeletal Disorders (WRSDs) are a common health problem and a major cause of disability. The aim of this study is to determine 12 months prevalence of musculoskeletal symptoms among radiologists and determine the relationship of ultrasonography practice posture and workload factors with those symptoms. About 23 (48.9%) of them were male and 24 (51.1%) were female. The mean age, total work hours per week and ultrasonography practice hours per week were 38.6±13.5, 29.9±12.2 and 23.3±9.6, respectively. Generally, report of anatomical regions pain was higher in man compared with women that it was significant (p = 0.05). There were not statically significant relation between anatomical regions pain and cases groups (p = 0.06). There were no significant relation between anatomical regions pain and ultrasonography practice hours (p = 0.4) and total working hours (p = 0.8). There were significant relation between total pain risk status and sex (p = 0.03), total working hours (p = 0.01) and age groups (p = 0.02). Also, there were significant relation between risk status of shoulder pain and age groups (0.002). There were significant relation between risk status of wrist pain and sex (0.04). WRSDs onset reported as a gradually, suddenly and known accident in 59.3, 31.7 and 10%, respectively. These findings suggest that the 6 months, prevalence of WRSDs among radiologists in Isfahan is not similar to prevalence reported in other study with values lower than their values. Also, there was no significant relation between anatomical regions pain and most of risk factors. We recommend performing further studies with more cases on radiologists.
  Alireza Rahimi , Babak Vahdatpour , Saeid Khosrawi , Alireza Mogtaderi , Soheil Sattari , Farnaz Dabiri and Omid Mashrabi
  Workload imposition is an important factor in the occurrence of musculoskeletal symptoms among the working groups. The purpose of this study is to determine the 12 months prevalence of musculoskeletal symptoms among pathologist and workload factors with occurrence of symptoms. In a cross-sectional study, pathologist population in Isfahan determined by using Medical Council Information Center. We took a photograph using digital camera when they were working with microscope. Data analyzed using Quick Exposure Check (QEC) for assessing exposure to WMSDs related risk factors. Among 51 pathologists, 37 (72.5%) of them was male and (27.5%) of them was female. The mean age, total work hours per week and working hours with medical instruments per week were 43.0±14.4, 46.5±17.9 and 36.9±18.6, respectively. The 12 months prevalence rates of WMSDs were highest in the neck (33.3%) and neck (21.6%) followed by the arm, shoulder (9.8%) and then elbow (7.8%) but least in the leg, wrist and wrist (5.9%). Among all of cases, 27.5, 41.2 and 31.4% had low, moderate and high working hours, respectively. Individual anatomical prevalence rate was high in the cases who were >30 years old compared with <30 that is not significant statistically (p = 0.1). Also, there were no significant relation between anatomical regions pain and sex (p = 0.2), total working hours (p = 0.03) and working hours with medical instruments (p = 0.08). The only statistically significant relation is relation between types of shoulder exposure risks and age groups (p = 0.08). These findings suggest that the 12 months prevalence of WMSDs among pathologist in Isfahan is similar to prevalence reported in other study but values are lower than their values. Also, there was no significant relation between anatomical regions pain and most of risk factors. We recommend performing further studies with more cases on pathologists particularly in whom working for long hours with medical instrument (microscope).
  Saeid Khosrawi , Alireza Rahimi , Babak Vahdatpour , Farnaz Dabiri Skouie and Omid Mashrabi
  Work-related Musculoskeletal Disorders (WMSDs) are common health problems and an important cause of disability among working groups including physicians. The aim of this study was to investigate the 12 months period prevalence of WMSDs in cardiologists. The study was conducted on Isfahan cardiologists’ population from whom 30 cardiologists entered the study. Researchers took a photograph using digital camera when they were performing echocardiography. Data analyzed using Quick Exposure Check (QEC) for assessing exposure to WMSDs related risk factors. The 12 months prevalence rates of WMSDs in cardiologists were highest in the lower back and neck (20%). Individual anatomical prevalence rate was high in the cases who were >40 years old compared with <40 (p = 0.6). There were no significant relation between anatomical regions pain and sex (p = 0.5), total working hours (p = 0.3) and echocardiography practice hours (p = 0.08). There was significant relation between types of shoulder exposure risks and age groups (p = 0.05). WMSDs among cardiologists were not related to advanced age and echocardiography practice hours. However, researchers recommend conducting further studies with more cases in future in order to determine relation between WMSDs and other risk factors in cardiologists, particularly in whom performing angiography as well as echocardiography.
  Fatemeh Lalooha , Faride Movahed , Talaat Dabaghi Ghaleh , Leila Alijani and Omid Mashrabi
  In traditional vaginal delivery used any intervention such as: IV line, prescription of oxytocin and episiotomy but in physiologic delivery did not do any intervention and exit of placenta was spontaneously and patient position in favorable situation. Comparing laceration and hemoglobin decrease in physiologic delivery and traditional vaginal delivery. Recent study are analytical epidemiologic study, case control that doing in 500 pregnant women who come to Kosar hospital with labor pain that randomly divided in two groups of traditional vaginal and physiologic delivery (250 cases in each group) and progress of delivery controlled then information an questionnaires completed. In recent study, in traditional vaginal delivery, 73.2% cases was used episiotomy. In physiologic group in 66.8% of cases there was not any laceration and 29.6% of cases grade I, 3.6% of cases laceration grade II. In traditional vaginal delivery in 26.8% of case there was not any episiotomy. That there was not laceration in 53.7%, 41.8% laceration grade I and 4.3% laceration grade II. The mean of Hb after 6 h of delivery in physiologic delivery was statically higher than traditional vaginal delivery (p<0.001). The findings show that the risk of laceration and decrease of Hb in physiologic delivery is less than traditional vaginal delivery. So, researchers can use physiologic delivery as routine.
  Faride Movahed , Talaat Dabaghi Ghaleh , Fatemeh Lalooha , Samaneh Aziziyan and Omid Mashrabi
  This study was done in order to study the effect of IV injection of hyoscine upon delivery progression. This double blinded clinical trial study was done on 140 term, cephalic presentation pregnant women who have not natural vaginal delivery were admitted in Kosar hospital in autumn 1388 for pregnancy termination. A sample was selected based on inclusion and exclusion criteria and randomized divided into two groups, 20 mg (l mL) hyoscine was given to group one and l mL distilled water was given to control group (group 2). These IV injections were done as single dose at the beginning of active labor. After that duration of the 1st, 2nd and 3rd stages of labor, maternal complications and caesarean section rate during labor and APGAR scores in the neonates were recorded. Then data was analysis by Chi-square (χ2) and t-test. The mean time for the 1st stage in the control group was 113.5±47.2 min, compared with 100.64±48.3 min in the hyoscine group that was statistically significant (p = 0.045). There was no significant change in the duration of the 2nd and 3rd stages of labor and no difference in APGAR scores noted at 1 and 5 min, there was a slight (but statistically insignificant) increase in the caesarean section rate. No adverse effect was noted in the group of women receiving hyoscine, compared with the control group. Hyoscine butyl bromide is effective in significantly reducing the duration of the 1st stage of labor and it is not associated with any obvious adverse outcomes in mother or neonate.
  Talaat Dabaghi Ghaleh , Fatemeh Lalooha , Faride Movahed , Simindokht Moradi and Omid Mashrabi
  Postpartum hemorrhage ranks among the leading causes of maternal morbidity and mortality, both in developed and developing countries. Intravenous Oxytocin is using now to reduce of postpartum hemorrhage. With this trial, researchers sought to determine the effectiveness of oral Misoprostol as an Uterotonic drug in comparison with intravenous Oxytocin in patients with a low risk of postpartum hemorrhage undergoing delivery. To compare the effect of 400 μg of oral Misoprostol with 10 IU of intravenous Oxytocin in preventing postpartum hemorrhage. In a randomized controlled trial conducted in Kosar hospital, 300 pregnant women with inclusion criteria received either 400 μg of oral Misoprostol or 10 IU of intravenous Oxytocin after delivery of the anterior shoulder or within 1 min of delivery. Hemoglobin and hematocrit of maternal was checked during admission and 24 h after delivery and compared together. There was no difference between two groups in hematocrit drop in 3.33±3.44 and 2.81±1.26% of the participants in the Oxytocin and Misoprostol group (p = 0.325). The rate of use of additional oxytocin was higher in the Oxytocin group (34.8 vs. 20.5%, p = 0.013). Shivering was higher in misoprostol group (12.3 vs. 2.9%, p = 0.005). Fever occurred only in 2 cases of Misoprostol group (p = 0.236). The routine use of 400 μg of oral misoprostol was no less effective than 10 IU of intravenous oxytocin in reducing blood loss after delivery as assessed by change in postpartum hematocrit and hemoglobin.
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