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The effect of some inhibitors [silver nitrate (AgNO3), paranitrophenyl oxamic acid (PNPO), Salicyl Oxamic Acid (SOA) and Ethylene Diamine Tetra Acetic acid (EDTA)] on dialysed Clostridium chauvoei (jakari strain) neuraminidase was investigated in vitro and it was found that these compounds inhibited neuraminidase activity. The concentrations of the inhibitors used were 1.5x103 然ol, 2.9x103 然ol, 4.4x103 然ol, 5.9x103 然ol and 7.4 然ol for all the inhibitors. Neuraminidase activity was measured by assaying the amount of sialic acid cleaved from fetuin by the enzyme on incubation with the substrate. In all studies, the inhibition was not proportional to the concentration of inhibitor used. It is suggested, based on the present results, that proper clinical trials should be conducted to ascertain the clinical application of these neuraminidase inhibitors in the management of blackleg in cattle.
