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Articles by Lawrence U.S. Ezeanyika
Total Records ( 2 ) for Lawrence U.S. Ezeanyika
  Anthony Cemaluk C. Egbuonu , Ambrose E. Ogbu , Ifeoma I. Ijeh and Lawrence U.S. Ezeanyika
  The sub chronic esculetin (6,7-dihydroxy-coumarin)-induced response on malondialdehyde concentration and some haematological and lipid metabolism parameters was studied in normal male Wistar rats to further understand the underlying esculetin metabolism and effects. Five groups (n = 6) of rats, A-E were respectively exposed to 6.0, 12.0 and 24.0 mg kg–1 b.wt. of esculetin, 0.2 mL of the vehicle control (10% dimethylsulfoxide (DMSO)) and 0.2 mL of the normal control (Distilled Water (DW)) per orally and daily for 28 days. Compared with the controls, the haematological parameters change in the esculetin-exposed rats was not significant (p>0.05) but decreased numerically with increasing dose viz: hemoglobin (99.83±5.04 g L–1-91±7.04 g L–1), packed cell volume (30±1.41%-27.33±2.16%), white blood cell count (9.63±0.91×109 L–1-7.95±0.58×109 L–1), neutrophil (1.93±0.51×109 L–1-1.72±0.34×109 L–1) and lymphocyte count (7.64±1.04×109 L–1-6.18±0.63×109 L–1). The reduction in the serum cholesterol (3.39±0.23 mmol L–1-3.01±0.78 mmol L–1) and triacylglyceride (0.49±0.45 mmol L–1-0.15±0.05 mmol L–1) concentrations in the esculetin-dosed rats was significant (p<0.05) and followed the numerical decreasing trend. The serum MDA concentration (1.90±0.53 mmol L–1-2.82±1.50 mmol L–1) decreased (p<0.05) but increased numerically with increasing dose. Thus, the sub-chronic esculetin-induced alteration was inversely related to esculetin dose and may not have resulted to significant pathologies or dysfunctional states in the rats.
  Chukwuonso E.C.C. Ejike , Paschal C. Ugboaja and Lawrence U.S. Ezeanyika
  The seeds of fluted pumpkin (Telfairia occidentalis Hook F.) are known to have some nutritional properties that suggest they are good food sources but their effects on growth and toxicity is not known. Twenty four adult male albino rats were divided into 4 groups: A, B, C and D. Group A served as the control group while groups B, C and D received 5, 15 and 45% boiled T. occidentalis supplemented diets for 21 days. Growth indicators and toxicity markers were assessed in all rats at the end of the study using standard protocol. The results show similar feed consumption index at the start and end of the study. Rats in the control group had the highest final weight (212.23±39.35 g) while those in groups C and D had slightly lower (though statistically similar) weights (192.03±23.64 and 192.01±27.98 g, respectively). Rats in group B weighed, however significantly (p<0.05) less (181.25±18.66 g) than the control group at 21 days. The percentage relative weight gain of the different groups was nevertheless proportional to the T. occidentalis content of the diets. Test rats also had better feed utilization index at week 3 relative to the control. The relative weights of the liver and kidneys of rats in the 4 groups and the levels of alanine and aspartate transaminases in the sera of the rats were similar (p>0.05). Dietary incorporation of the seeds of T. occidentalis resulted in good growth and did not have any detectable toxicity after 21 days. Other aspects of health that may be affected by the consumption of oil-seeds need to be investigated.
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