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The acute, sub-acute and chronic toxicity were conducted on Victoria 1500 and 2000 capsules which contains royal jelly, panax ginseng and yohimbe park, all individually have not shown any toxicity on long term administration. Study was planned to assess the safety of the combination by doing toxicity studies. Toxicity studies were done in two animal models by using mice and rats. Acute, sub-acute and chronic toxicity studies were undertaken by treating nimals with a single dose of 15 times the recommended dose for acute, 5 times recommended dose administered orally each other day for 7 days for sub-acute and a daily recommended dose for 6 months for chronic toxicity studies. In acute and sub-acute toxicity studies histopathological results confirmed all vital organs to be normal. The results of the biochemical and hematological studies revealed some changes in some parameters of the treated animals. In sub-acute an increase in RBC and hemoglobin levels was shown. Treatment showed no spermatotoxic activity. During chronic toxicity study, the visceral condition of the animals and histopathological investigations were found to be normal. There were no drastic changes in the biochemical and hematological parameters and the results of the sperm count, sperm motility and sperm viability, respectively were found to be: ≥14x106 mL-1, ≥50 and ≥50%.