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Articles by Fang Yi
Total Records ( 3 ) for Fang Yi
  Liu Wu Jun , Fang Yi , Shao Yong-gang , Fang Guang Xin , Tian Ke Chuan , Huang Xi Xia , Chen Hong and Zhang Fu Quan
  In this study, a novel deletion mutation in the whole CDS region at cashmere goat KAP16.5 gene locus is reported, which result showed the deletion of KAP16.5 gene in 816 cashmere goat samples was firstly detected in China. At the same time, parts of these samples sequenced. However, there are not many studies of goat KAP16.5 gene and its polymorphisms in literary sources. The polymorphism was studied in three Xinjiang local goat breeds of China. The results showed that there was 15 bp-deletion mutation in this gene. The frequencies of the KAP16.5-Y allele in Xinjiang goat (n = 220), Nanjiang cashmere goat (n = 310) and BoGeDa cashmere goat breeds (n = 286) were 0.9591, 0.8694 and 0.8846, respectively. The χ2-test showed that the genotype distributions in these three cashmere goat breeds were not in agreement with Hardy-Weinberg equilibrium. According to the classification of PIC, Nanjiang cashmere goat was more polymorphic at this locus. Moreover, the 15 bp-deletion mutation was described at KAP16.5 locus for the first time and not have described at KAP16.5 locus. Then, the deletion polymorphisms within the KAP16.5 have been associated with economic production traits data in Nanjiang cashmere goat breed shown no significant (p>0.05).
  Wang Qiong , Fang Chao , Liu Wu-Jun , Fang Yi and Yu Shi-Gang
  This study was designed to analyze the association between polymorphisms of insulin-like growth factor-1 (IGF-1) and cashmere production traits (fineness, thickness and yield) and body weight. PCR-SSCP (single-strand conformational polymorphism) and DNA sequencing were used to detect polymorphisms of IGF-1 gene in 776 samples of three Xinjiang local goat breeds (Xinjiang, Bogeda Cashmere and Nanjiang Cashmere Goat). The obtained results showed that the frequencies of genotype AA were 0.414, 0.591 and 0.319. Genotype AB were 0.000, 0.126 and 0.029. Genotype BB were 0.586, 0.241 and 0.597 and genotype AC were 0.000, 0.042 and 0.055 for Xinjiang, Bogeda Cashmere and Nanjiang Cashmere Goat breeds, respectively. The mutation was detected at IGF-1-P1 locus, a novel of SNP was revealed in exon 4 (Genebank D26119: c.1617 G >A, c.1620 C>T) and they belong to silent mutation, which was the first reported in international goat. In addition, a novel of SNP at IGF-1-P1 locus is significantly associated with cashmere production traits. In Nanjiang Cashmere Goat population, the cashmere fineness of AA genotype individual was significantly (p<0.05) lower than that of AB genotype. The body weight of AC genotype individual was significantly (p<0.05) higher than that of BB genotype.
  Liu Wu-Jun , Fang Guang-Xin , Fang Yi , Tian Ke-Chuan , Huang Xi-Xia , Yao Xin-Kui , Wang Mou , Yu Hui , Huang Yong-Zhen , Xin Jing-Jing , Xin Ya-Ping , Yu Shi-Gang and Chen Hong
  Searching for effects of candidate gene polymorphisms on cashmere production traits is an important goal for goat industry. Genetic variations in IGF-1 may alter protein function. This study investigated the association between polymorphisms in insulin-like growth factor-1 (IGF-1) and cashmere traits data with two Xinjiang local goat breeds. The results showed IGF-1-P1 locus has polymorphisms. The polymorphism locus of IGF-1-P1 by PCR-RFLP and DNA sequencing methods in 530 individuals from two Xinjiang local goat breeds in China. The frequencies of genotype AA in two goat breeds (Xinjiang goat, Nanjiang cashmere goat) were 0.487 and 0.277. Genotype BB was 0.274 and 0.486. Genotype AB was 0.239 and 0.236. The polymorphisms of the IGF-1 gene were associated with cashmere yield, fiber diameter, body weight in cashmere goat. However, concern on cashmere production traits among three genotypes were shown not significantly (p>0.05).
 
 
 
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