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by
A. Cacioppo |
Total Records (
4 ) for
A. Cacioppo |
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G.A. Scardina
,
A. Ruggieri
,
F. Carini
,
A. Cacioppo
,
V. Valenza
and
P. Messina
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The aim of this study is the comparative evaluation of the serum levels of retinol in patients affected by leukoplakia and oral lichen planus. The study has been conducted through a statistical investigation with the purpose to underline possible variations of such levels, provided that meaningful, between the two groups. The retinol, an important molecule belonged to the family of retinoids, has an important anti-oxidant action and for this characteristic it can neutralize metabolic products (including reactive oxygen species), interfere with activation of procarcinogenes, prevent binding of carcinogens to DNA, inhibit chromosome aberrations, restrain replication of the transformed cell, suppress actions of cancer promoters and it may even induce regression of precancerous oral lesions. Leukoplakia and Oral Lichen Planus are oral precancer lesions with a greater potential of neoplastic malignant transformation that often show a strong subepithelial accumulation of inflammatory cells. Serum levels of retinol were estimated by the High Performance Liquid Chromatography (HPLC) method. Statistical analysis has been conducted with the Mann-Whitney U-test and we used P.A.S.T., ver. 1.53; a freeware developed by P.D. Ryan, D.A.T. Harper and J.S. Whalley in 1995 and up-to-date to the last version in September 2006. No significant differences were noticed in retinol serum levels in leukoplakia and oral lichen planus cases examined in this study. This result suggests that low serum retinol levels are not risk factors for occurrence of leukoplakia and oral lichen planus.
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G.A. Scardina
,
A. Ruggieri
,
F. Carini
,
A. Cacioppo
,
V. Valenza
and
P. Messina
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The Hodgkin`s disease, also known as Hodgkin`s lymphoma, is a cancer of the lymphatic system. Its origin, pathogenesis and characteristics cell constitution are clear as also the diagnostic algorithm and the therapeutic manage. The aim of this research is to describe the oral manifestations of the disease: Complications of the treatment or lesions associated to other diseases as disckeratosis congenital or the follicular lymphoid hyperplasia of oral cavity. These associations have been studied even if their pathogenetic mechanisms are unclear. It`s also important, in dentistry, the confirmed association with the Sjogren syndrome and the primary manifestation of the Hodgkin`s lymphoma in the parotid gland, which is possible and reported in literature but rare and actually object of research.
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G.A. Scardina
,
A. Ruggieri
,
F. Carini
,
A. Cacioppo
,
V. Valenza
and
P. Messina
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The Nuclear Factor- k B (Nf-k B) is a Factor of Transcription (FT) ubiquitin preserved in the eukaryotic cells. Nf-k B is activated by numerous stimuli including viral and bacterial products, ultraviolet radiations, oxidant radicals, cytokines and various chemical substances. Once activated, Nf-k B directly checks, or with the cooperation of other factors of transcription, the activity of over 100 genes that produce cytokines, factors of growth, chemokines, molecules of adhesion, proteins of the acute phase. The transcriptional factor NF-k B is implicated in the pathogenesis of chronic inflammatory disease of the vascular system and in the process of formation of atherosclerotic lesions. In fact, NF-k B, in the activated state, is identified in situ in atherosclerotic human plates, while it’s absent in vases exempted by atherosclerotic lesions. Recent study has shown that the infection by HSV-1 is able to activate NF-k B in persistent way and to higher levels respect to the others deriving from subsequent exposure to inflammatory cytokines in various types of human cells. Moreover, the virus interferes with the self-regulating system of NF-k B, with consequent exacerbation of the inflammatory state. For this reason, NF-k B could represent an interesting target for new chemotherapic drugs with anti-viral action and anti-inflammatory in the herpetic infections. The biggest part of the anti-inflammatory actions of the Glucocorticoids (GC) depends by their ability to interfere with the functions of transcription factors, such as NF-k B. Tissue lesions, cytokines, free radicals and oxidized damages induce the activation of the NF-k B, whose action determines increase of the synthesis of COX2 and therefore of the production of some prostaglandins with pro-inflammatory function. Finally, the inhibition of the COX2 and NF-k B operated by the FANSs has shown, in some cases, benefits anticancer effects. For all of these influences on many pathologic processes, Nf-k B can be considered as target of pharmacological treatment and object of continuous studies. |
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G.A. Scardina
,
G. Fuca
,
A. Ruggieri
,
F. Carini
,
A. Cacioppo
,
V. Valenza
and
P. Messina
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Oral candidiasis is an opportunistic infection of the oral cavity. It is common and underdiagnosed among the elderly, particularly in those who wear dentures and in many cases is avoidable with a good mouth care regimen. It can also be a mark of systemic disease, such as diabetes mellitus and is a common problem among the immunocompromised. Oral candidiasis is caused by an overgrowth or infection of the oral cavity by a yeast-like fungus, candida.The important ones are C albicans, C tropicalis, C glabrata , C pseudotropicalis, C guillierimondii, C krusei, C lusitaniae, C parapsilosis and C stellatoidea. C albicans, C glabrata and C tropicalis represent more than 80% of isolates from clinical infection. Oral candidiasis is the most common human fungal infection especially in early and later life. The incidence varies depending on age and certain predisposing factors. There are three broad groupings consisting of acute candidiasis, chronic candidiasis and angular cheilitis. Chronic hyperplastic candidosis/candidiasis (CHC; syn. candidal leukoplakia) is a variant of oral candidosis that typically presents as a white patch on the commissures of the oral mucosa. Risk factors include impaired salivary gland function, drugs, dentures, high carbohydrate diet, smoking, diabetes mellitus, Cushing`s syndrome, malignancies and immunosuppressive conditions. The aim of the research is to describe the clinical manifestations of the disease.
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