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| Articles
by
Y. Karumi |
Total Records (
3 ) for
Y. Karumi |
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Y. Karumi
,
A.I. Augustine
and
I.A. Umar
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Aqueous extract of Adansonia digitata inhibit ethanol-induced gastric ulceration in rats. Oral pretreatment with Adansania digitata (150-600 mg kg-1) caused significant dose-dependent increase both in preventive ratio and percentage ulcer reduction. This effect might in part be due to its astringent, flavanoids and anti-oxidant properties earlier reported.
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Y. Karumi
,
P.A. Onyeyili
and
V.O. Ogugbuaja
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Momordica balsamina leaf was investigated for it`s chemical and traces elemental content. The air-dried samples were subjected to soxlet extraction using the solvents petroleum ether, methanol and water of different polarities. The extract fractions were concentrated and subjected to phytochemical screening to identify which component was high in concentration. The aqueous fraction, which is commonly used by traditional herbal healers, was further, subjected to column chromatographic separation and the recombined fraction of the column was further subjected to thin layer chromatography for identification. The air-dried sample was digested and analyzed for trace elements using atomic absorption spectroscopy. The phytochemical analysis revealed the presence of alkaloid in high concentration followed by saponins, tannins and reducing compound, respectively. Sterols and triteperes were absent in all the solvents used. The analysis of the recombined column fraction of the aqueous extract indicated the presence of the tannins in two of ten fractions, alkaloids in four, saponins in two and the last fraction indicated the presence of reducing compounds. The thin layer chromatography identified the presence of alkaloids, saponins and tannins in the different fractions of the column. In conclusion therefore, M. balsamina as shown here do posses some active chemical constitutes like alkaloids, tannins, saponins, Fe, Zn and Mn. |
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Y. Karumi
,
P. Onyeyili
and
V.O. Ogugbuaja
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The effect of aqueous leaves extract of M. balsamina on acetic acid induced writhes/stretches
(Anti nociceptive/analgesic effect) and egg albumen induced edema (Anti-inflammatory
effect) was studied. Three different doses of the leaves extract were administered to three
groups of rats 30 minutes prior to the administration of acetic acid. Pentzocin was used as
the standard Analgesic drug. Another Randomized Block Design of three blocks was
administered with three different doses of the leaf preparation 30 minutes prior to the
induction and oedema with egg alburnen. Pure aspirin was used as the standard anti-inflammatory agent. The treatment with the plant preparation cause dose dependent
significant (p<0.05) protection against the writhes/stretches produced by acetic acid
administrations and oedema induced by egg albumen. These protections were found to be
superior to those of the standard drugs used. The result of the findings establishes the
analgesic and anti-inflammatory effect of the aqueous extract of M. balsamina and concludes
therefore, that there was a positive correlation (r = 90) in the dose response relationship for
both analgesic and anti-inflammatory effect. |
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