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The changes in electrical activity of the cerebral cortex during amylobarbitone anaesthesia were studied in rabbits. Electrical activity of the rabbit cerebral cortex recorded (using an oscilloscope), sixty minutes after induction of amylobarbitone (30 mg kg-1, body weight, I.P.) anaesthesia did not significantly differ from control values obtained before anaesthesia or 24 h after recovery from anaesthesia. Amylobarbitone administered @ 60, 90 and 120 mg kg-1 body weight significantly (P<0.05) and dose-dependently decreased the cerebral electrical activity. Therefore, amylobarbitone at the dose of 60 mg kg-1 body weight or higher may cause depression in the electrical activity of the rabbit brain.