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by
S. Qureshi |
Total Records (
5 ) for
S. Qureshi |
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A.M. Aleisa
,
S.S. Al-Rejaie
,
S.A. Bakheet
,
A.M. Al-Bekairi
,
O.A. Al-Shabanah
,
Abdulhakeem Al-Majed
,
Abdulaziz A. Al-Yahya
and
S. Qureshi
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Diabetes Mellitus (DM) is a chronic disease that is characterized
by deterioration of glycemic control. The disease is known to be caused
by imbalance between Reactive Oxygen Species (ROS) and antioxidant defense
systems. Hyperglycemia is commonly observed in a wide variety of diseases,
including cancer. Although, therapy against glycemic control is used in
all these diseases, the diabetic cancer patients are on additional therapy
with anticancer drugs. The objective of present study was to investigate
if metformin, a very popular antidiabetic agent can avert the cardiac
and hepatic toxicity caused by Adriamycin (ADR), which is a commonly used
cytotoxic drug. The experimental protocol included oral treatment of mice
with different doses (62.5, 125 and 250 mg kg-1 day-1)
of metformin for 7 days. Some mice in each group were injected i.p. with
ADR (15 mg kg-1), 24 h prior to sacrifice. In each case animals
were killed, 24 h after the last treatment, blood sample was collected
and plasma was separated for analysis of AST, ALT and CK-MB. Liver and
heart from the same animals were excised for analysis of proteins, nucleic
acids, MDA and NP-SH. The results obtained revealed that pretreatment
with metformin (i) reduced the ADR-induced increase in the concentrations
of AST, ALT and CK-MB (ii) protected against the ADR-induced increase
of MDA and decrease of DNA and NP-SH in both cardiac and hepatic tissues.
These results demonstrate that the treatment with metformin might be useful
to protect cardiac and hepatic toxicity. The exact mechanism of action
is not known, however; the inhibition of ADR-induced increase of plasma
enzymes and MDA and depletion of DNA and NP-SH by metformin may be attributed
to its antioxidant potentials, which are well known for the reduction
of glycotoxins and general improvement in cellular dysfunction. The use
of Metformin by cancerous diabetic patients on cytotoxic therapy will
be a boon to avert the cardiac and hepatic toxicity. |
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Abdurrahman Al Diab
,
S. Qureshi
,
Mohammad Farhan Qureshi
,
Viquar Fatima Qureshi
and
Mohammad Rehan Qureshi
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Behind the alluring fame of established drugs in a magical cure of some types of cancers are myriad toxicities. Hence, it became imperative to search alternative approaches of treatment. Although a large number of papers are published to show that herbs, plant products and their constituents are capable to inhibit the growth of a variety of human colon carcinoma cell lines, there is a gross neglect on an impact of in vivo outcome which show overall effects. The present study on an experimental approach to treatment of Colorectal Cancer (CRC) by herbs, plant products and their constituents was undertaken to review the (1) adverse effects of established drugs used against CRC, (2) herbs, plant products and their constituents as alternatives to established drugs, (3) in vivo studies on herbs, plant products and their ingredients, (4) in vitro studies on herbs, plant products and their ingredients, (5) pros and cons of in vivo and in vitro studies, (6) molecular targets and (7) conclusion. The articles included were peer reviewed English language articles published up to November 2011. These were selected from Pub Med, Pub Med Central, Science Direct, Up-to-date, Med Line, Comprehensive databases, Cochrane library and the internet (Google, Yahoo). The search strategy corresponded with points, 1-6 above. The literature obtained is reviewed. It is suggested that the laboratories working on CRC with in vitro protocol may also undertake confirmatory in vivo experimentation with an application of gene expression profiling using microarray technologies. |
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S.K. Prasad
,
Taj N. Qureshi
,
S. Saxena
,
S. Qureshi
,
M. Mehar
and
S.K. Thakur
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It is obvious from several studies that the different neurotransmitters are associated with various metabolic activities of the body directly or indirectly via their effects on hypothalamic/pituitary hormone but regarding the control of reproductive system catecholamines seem to have a central role. In view of above fact the present study was designed to test whether neurotransmitter precursor L-Dihydroxyphenylalanine (i.e. L-DOPA, a dopamine precursor) feeding, can influence body growth and reproductive conditions in high food value poultry bird Japanese quail, Coturnix coturnix japonica. Experiments were performed in both male and female Japanese quail. Sexually immature (one week old) quail chicks were divided into two groups of 24 birds each. Group-I provided with normal diet and served as control while Group-II (experimental group) provided with food mixed with L-DOPA (50 mg/15 gm food). At the age of 3 weeks (when birds were sexually distinguished) Group-I was divided into two sub groups IA (male) and IIA (female) of six birds each. Similarly Group II was sub divided into IB (male) and IIB (female) of 6 birds each. Observations were made up to the age of 5 weeks. Male experimental group (IB) showed significantly increased testicular activity, cloacal gland volume, body weight, plasma testosterone and LH level in comparison to control (IA). Similarly female experimental group (IIB) showed significantly high weight of reproductive organs (uterus, ovary, oviduct, ovarian follicle), body weight, egg weight and size and number of follicles. On the other hand plasma prolactin level was significantly low in comparison to control (IIA). Results suggest that the development and reproduction in Japanese quail might be associated with dopaminergic system of the brain. |
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Abdullah Foraih Al-Anazi
,
Abdurrahman Al Diab
,
Mohammad Farhan Qureshi
,
Viquar Fatima Qureshi
,
Mohammad Rehan Qureshi
and
S. Qureshi
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Consanguineous marriages are the crucial factors for several genetic disorders
and dreadful syndromes which are the bases of morbidity and mortality in the human
population. The genetic disorders are linked to abnormalities in either p or q
arms of specific chromosomes. However, reports in the literature are not firm
on specificity of phenotypic response to the precise genomic region. In view of
a paucity of literature on the subject and the controversies arising with respect
to the discordance in phenotypic response, this particular case was found interesting
for a report in the literature. This is about a baby whose mother was married
to her cousin (a consanguineous marriage). The parents had a family history of
cerebral palsy and mental retardation. Genetic analysis of the baby showed deletion
at 5p14 and the father had translocation between chromosome 5p13 and 10p14 while
the mother was genetically normal. The baby was born healthy but had several complications,
till he died at the age of 5. The different complications that the baby suffered
included: delayed motor activity and developmental disabilities, psychological
derrangement, mental retardation, frequent convulsions, microcephali, delayed
speech and language development, dysmorphic face, low set ears and hyper reactivity.
There was gross discordance in the specific genome region and the phenotypic observations
which appears to be due to the interaction between different loci at 5p in addition
to epigenetic influence. |
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Abdurrahman Al Diab
,
S. Qureshi
,
Khalid A. Al Saleh
,
Farjah H. Al Qahtani
,
Aamer Aleem
,
Mohammad Farhan Qureshi
,
Viquar Fatima Qureshi
and
Mohammad Rehan Qureshi
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Literature reports suggest a tremendous decline in the global incidence, mortality and morbidity of Colorectal Cancer (CRC) during the post-millennium as compared to the pre-millennium. These developments are attributed to the advancement in technicalities and researches. The status of CRC in the Kingdom of Saudi Arabia (KSA) during the pre-millennium restricted to most of the etiological, histological and epidemiological researches while progress around the world had already begun studies on molecular level. During the third millennium, there are active genome level researches in addition to the development of the link of MicroRNAs with progression of cancer. Although, research on gene expression began in KSA but its involvement in the discovery of newer compounds is still a vision. Furthermore, the researches in KSA lag behind in the new developed era of MicroRNAs. This review on the development of research activities on CRC has revealed that researches in KSA are slow and late but do not lag behind in the global scientific maneuvers taking place in the third millennium. |
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