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Sentinel lymph node (SLN) biopsy in breast cancer is an emerging technique that decreases surgical morbidity. SLN was successfully identified as blue node with blue lymphatic after intradermal injection of isosulfan. The breast tumor was clinically palpable having a size of 4cm in upper and out quadrant of right breast with non palpable axillary lymph nodes. The tumor malignancy was documented pre-operativly by excision biopsy. SLN biopsy offers an ideal staging procedure for early breast cancer patients. SLN biopsy is a simple, inexpensive and accurate procedure in breast cancer patients whose axillary nodes are non-palpable .