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Articles by Qian Liu
Total Records ( 2 ) for Qian Liu
  Xiujuan Guo , Shurong Wang , Zuogang Guo , Qian Liu , Zhongyang Luo and Kefa Cen
  Molecular distillation was used to separate bio-oil into a light fraction, a middle fraction and a heavy fraction. The chemical composition of the three fractions and the crude bio-oil was analyzed by gas chromatography coupled with mass spectrometry (GC-MS). The diversity of the components reflected the complexity of the bio-oil and the necessity for fractionation. The pyrolysis characteristics of the bio-oil fractions were determined with a thermogravimetric analyzer coupled with Fourier transform infrared spectroscopy (TG-FTIR). The weight loss of components was in agreement with the chemical composition. The light fraction evaporated fastest with the formation of water, CO2, hydrocarbons and alcohols. The heavy fraction had the slowest rate of decomposition and the highest char residue yield due to the presence of phenols and saccharides, and the pyrolysis products included CO2 and alcohols or phenols, which was similar to the middle fraction except the formation of water and formic acid. The release of CO or methane, evidence of a secondary reaction, began at not, vert, similar450 °C in the pyrolysis of the light and middle fractions.
  Wei-hui Wu , Peng Lei , Qian Liu , Jia Hu , Adam P. Gunn , Mei-sha Chen , Yan-fang Rui , Xiao-yang Su , Zuo-ping Xie , Yu-Fen Zhao , Ashley I. Bush and Yan-mei Li
  Decelerated degradation of β-amyloid (Aβ) and its interaction with synaptic copper may be pathogenic in Alzheimer disease. Recently, Co(III)-cyclen tagged to an aromatic recognition motif was shown to degrade Aβ in vitro. Here, we report that apocyclen attached to selective Aβ recognition motifs (KLVFF or curcumin) can capture copper bound to Aβ and use the Cu(II) in place of Co(III) to become proteolytically active. The resultant complexes interfere with Aβ aggregation, degrade Aβ into fragments, preventing H2O2 formation and toxicity in neuronal cell culture. Because Aβ binds Cu in amyloid plaques, apocyclen-tagged targeting molecules may be a promising approach to the selective degradation of Aβ in Alzheimer disease. The principle of copper capture could generalize to other amyloidoses where copper is implicated.
 
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