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IL-17 is a crucial mediator of mucosal inflammation for extracellular bacteria clearance. The production of IL-17 was associated with TGF-β and multiple proinflammatary cytokines, especially IL-6 and IL-1β. IL-17 can cooperate additively or synergistically with IL-6 or IL-1β to amplify of inflammatory processes. However, the roles of IL-17 and cytokines associated with IL-17 in dairy goat mastitis is poorly understood. In the present study, the concentrations of IL-17, IL-6, IL-1β and TGF-β were assayed in sera and milk of Guanzhong dairy goat mastitis induced with Escherichia coli using the Enzyme-Linked Immunosorbent Assay (ELISA) at several time points before and after challenge. The results showed that the levels of all cytokines varied slightly in sera while raised significantly in milk post intramammary inoculation with E. coli. The results suggest that IL-17 is one of important mediators in mammary gland inflammation for bacterial clearance in dairy goat mastitis and IL-6 and TGF-β play an important role or help for development in IL-17 producing cells in goat.