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| Articles
by
Ke Li |
Total Records (
3 ) for
Ke Li |
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Ke Li
,
Hua Zhao
,
Ji-Chang Zhou
,
Jia-Yong Tang
,
Xin-Gen Lei
,
Kang- Ning
and
Wang
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This study was to develop an obese porcine model induced by a high-fat diet and determine effects of obesity on gene expression in subcutaneous fat tissue in this model. A total of 20 crossbred, castrated boars (20 kg body weight) were fed a corn-soy basal diet (Se adequate, total fat <0.82%) or the diet added with lard at 3% (20-50 kg), 5% (50-80 kg) or 7% (>80 kg) for 180 days. Results showed that pigs fed the high fat diet showed greater (p<0.05) body weight (146 vs. 121 kg), back fat thickness (3.5 vs. 2.3 cm) and abdominal fat content (3.5 vs. 1.9 kg), along with hyperglycemia and hyperlipidemia, compared with the control pigs. About 387 genes were found to be significantly up-regulated and 465 genes down-regulated (fold change ≥2.0) in the high-fat diet group compared to the control group. To further characterize the response of gene type to high-fat diet in subcutaneous fat tissue, 852 genes significantly altered in response to high-fat diet were classified into Gene Ontology (GO) slim terms. Genes involved in metabolic process, immune response, translation and cell cycle were significantly up-regulated (p<0.05). Genes involved in regulation of transcription, RNA splicing and transcription were significantly down-regulated (p<0.05). The results indicated that the differentially expressed genes including 26 up-regulated and five down-regulated genes were associated with significant pathways involved in organization of metabolism and primary immunodeficiency (NSFC projects 30871844, 30700585). |
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Hui-lu Wu
,
Xingcai Huang
,
Jingkun Yuan
,
Ke Li
,
Jian Ding
,
Ruirui Yun
,
Wenkui Dong
and
Xuyang Fan
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A five-coordinate copper(II) complex with the tripod ligand tris(N-methylbenzimidazol-2-ylmethyl)amine
(Mentb) and salicylate, with the composition [Cu(Mentb) (salicylate)](ClO4)
· 2DMF, was synthesized and characterized by elemental and thermal analyses,
electrical conductivity, IR and UV-Vis spectral measurements. The crystal structure
of the complex has been determined by single-crystal X-ray diffraction. The Cu(II)
is five-coordinate with four N atoms from the Mentb ligand and an O atom of the
monodentate salicylate ligand. The N4O donors are in a distorted trigonal-bipyramid
geometry. Cyclic voltammograms indicate a quasireversible Cu2+/Cu+
couple. The X-band EPR spectrum of the complex confirms the trigonal-bipyramidal
structure with g∥ < g⊥ and
a very small value of A∥ (41 x 10-4 cm-1). |
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Hui-Lu Wu
,
Rui-Rui Yun
,
Kai-Tong Wang
,
Ke Li
,
Xing-Cai Huang
,
Tao Sun
and
Yao-Yu Wang
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A ligand 1,3-bis(1-benzylbenzimidazol-2-yl)-2-oxopropane (Bobb) and the zinc(II) complex, [Zn(Bobb)2](picrate)2 · 2DMF, were synthesized and characterized by elemental analyses, electrical conductivities, IR, and UV. The crystal structures of the ligand and the zinc complex have been determined by single crystal X-ray diffraction. The ligand displays a V-shaped configuration and the Zn(II) cation is six-coordinate by four nitrogens and two oxygens from Bobb. The N4O2 donor set is a distorted octahedron. |
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