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| Articles
by
Kasra Hamdi |
Total Records (
2 ) for
Kasra Hamdi |
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Amir Ghaemi
,
Kasra Hamdi
,
Mansoureh Togha
,
Hadi Kazemi
and
Ali Gorji
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The Matrix Metalloproteinase Proteins (MMPs) comprise a large group of endoproteinases that cleave most, if not all, components of the extracellular matrix. The activities of MMPs are modulated by manipulation in the levels of natural MMP inhibitors, the “Tissue Inhibitors of Metallo Proteinases” (TIMPs). In a pathological processes of Multiple Sclerosis (MS), the MMP-2 and 9 (Gelatinase) are over expressed and balance of TIMP and MMP expression is perturbed, leading to locally increased proteolytic activity of Gelatinase and uncontrolled degradation of the Blood Brain Barrier (BBB) and myelin basic protein. Therefore, Gelatinase are the main mediators in the evolution of MS and TIMP has been proposed as a novel therapeutic target for MS therapy. |
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Alireza Shoae Hassani
,
Nour Amirmozafari
,
Negar Ordouzadeh
,
Kasra Hamdi
,
Rashed Nazari
and
Amir Ghaemi
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This study aimed to evaluate the efficacy of semi fermented
and non fermented Camellia sinensis extracts (Black and Green tea)
and comparison between them against Streptococcus mutans ATCC
25175, S. mitis ATCC 9811 and S. sanguis ATCC 10556 that
are responsible for dental caries and bacteremias following dental manipulations.
Minimum inhibitory concentrations of both tea extracts were assessed by
Well diffusion and Broth dilution methods and examination of cell adherence
(Biofilm inhibitory concentrations) was observed on glass slides under
phase contrast microscope and colony counts from glass beads. Concentration
of 1 mg mL-1 of semi fermented tea extract was completely biofilm
inhibitor but biofilm formation by these bacteria was seen 7 days after
treatment with 1 mg mL-1 of non fermented Camellia sinensis
on glass beads and BIC for oral streptococci treated with this extract
was 1.5, 2.5 mg mL-1 of semi fermented and 3 mg mL-1
of non fermented extracts had bactericidal effect on these bacteria. Semi
fermented and non fermented Camellia sinensis extracts were able
to prevent growth of oral streptococci. Therefore dental caries significantly
reduce and the efficiency of semi fermented tea was higher due to rich
content of volatile components rather than non fermented extracts. |
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