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The aim of this study is to present the clinical and pathological findings occurring in a natural outbreak of Carbadox poisoning in pigs. Carbadox was administrated as much as four times the recommended dose (210 ppm) at least during the fattening period. Clinical signs included emaciation, dry feces, pica, ataxia, tremor and nervousness in some animals. Postmortem examination showed dehydration, gastric ulcers, bronchopneumonia, hydrothorax and hydropericadium. Microscopically, the most significant lesions were atrophy of glomerulosa zone in the adrenals with hydropic degeneration and necrosis of the remaining cells. Diagnosis was based on clinical history and lesions in the adrenal cortex, which are considered characteristics.