Asian Science Citation Index is committed to provide an authoritative, trusted and significant information by the
coverage of the most important and influential journals
to meet the needs of the global scientific community.
Rapid urbanization of our world has lead to accumulation of enormous number of contaminants in our environment. Heavy metals hold a superlative position in that list and are responsible of contaminating soil, water and all food stuffs taken up by the humans. The presented work was an effort to develop a biopolymer membrane which efficiently bonded and removed heavy metals like lead from the water sample. It was also found to be a very good matrix for enzyme immobilization in developing heavy metal biosensor. The membrane bonded to the positively charged heavy metal cations and lead to their preconcentration from the samples. The synthesized membrane was a hybrid of hydrosol-gel and alginate in a ratio which lead to the formation of a thin film that acted as the preconcentration medium in the study. It had been found to be an efficient electron transfer facilitator for application in electrochemical biosensor.
Drug release from polymers may be erosion or diffusion based or combination of these processes. Various equations and models are available for relating drug release. Most of the decisions are made on basis of similarity of original and predicted release profiles (predicted by fitting release data in various models or equations). In this study, decision for release pattern has been made on basis of SSR/R2 for model drug ofloxacin from laboratory developed Extended Release (ER) matrix tablets. Three batches A, B, C having HPMC, sodium alginate and 50:50% mixture of HPMC:sodium alginate were prepared. The USP Dissolution apparatus 2 was used for ofloxacin release and swelling-erosion studies of different batches in SGF, buffer of pH 6.2 and SIF. The batch C, ofloxacin matrix tablet composition was finalised on basis of <30% release within 1 h in SGF, >85% release upto 8 h in SIF and conformity to shape of profile within 1-7 h dissolution in buffer of pH 6.2. Instead of use of SSR and R2 on individual basis, SSR/R2 expressed ofloxacin release mechanisms in good agreement to physically observed swelling-erosion behaviors of matrix tablets in all pH conditions.