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Articles by G. Oze
Total Records ( 4 ) for G. Oze
  H.U. Nwanjo , N.J.C. Okolie , G. Oze , M.C. Okafor , D. Nwosu , C. Ajero , B. Anyaehie , G.C. Uloneme , C.J. Njoku and P. Nwamkpa
  Halofantrine is a phenanthrene methanol, belonging to the aryl-amino alcohol family, which is widely prescribed for the treatment of infections with chloroquine-resistant strains of Plasmodium falciparium. This study examined biochemical evaluation of hepatic dysfunction as a result of halofantrine toxicity in Wistar rats. Various concentrations of halofantrine (30, 60 and 90 mg kg 1 were administered to the three groups of Wistar rats. The fourth group of animals received distilled water (control). The body weight changes and the relative weight of the liver were measured. The serum hepatospecific markers such as Aspartate Transaminase (AST), Alanine Transaminase (ALT), Alkaline Phosphatase (ALP) activities and serum total bilirubin level were also estimated. The halofantrine treated groups had a significant increase in the relative weight of their livers (p< 0.05) when compared with control. There was also significant increase in all the enzymes and total bilirubin (p< 0.05) when compared with control. The results indicated that halofantrine might have hepatotoxic effect in Wistar rats.
  H.U. Nwanjo , N.J.C. Okolie , G. Oze , M.C. Okafor , D. Nwosu , C. Ajero B. Anyaehie , G.C. Uloneme , C.J. Njoku and P. Nwamkpa
  This study was done to establish the effects of co-administration of chloroquine with aspirin on kidney function. We monitored renal parameters such as urea, creatinine and electrolytes. The experimental animals were divided into 4 groups. Group 1 received only food and water (control). Group 2-4 received in addition to food and water either single dose with aspirin (8 mg kg 1 body weight day 1), chloroquine phosphate (5 mg kg 1 body weight day 1) or combined therapy of chloroquine and aspirin for 8 days. The chloroquine-treated group showed a significant increase in mean serum urea and creatinine levels (p< 0.05) and significant decrease in mean serum sodium and potassium levels (p< 0.05) when compared with the corresponding values of the control group. This study also revealed that co-administration of chloroquine and aspirin caused a more pronounced decrease in serum sodium and potassium levels. The results of the study suggest that acute administration of chloroquine may affect kidney function, more so when co-administered with aspirin; two drugs sometimes combined in the treatment of malaria in a malaria endemic country such as Nigeria.
  C.M.U. Ajero , B.E.B. Nwoke , N.J.C. Okolie , H.U. Nwanjo , G. Oze , M.C. Okafor , D. Nwosu , B. Anayaehi and G.C. Uloneme
  A study was carried out to identify the intestinal nematode transmitted by Cyclorrhaphan files in a market environment. Three cyclorrhaphan species were identifies namely, Musca domestica, Musca sorbens, Chrysomya megacephala. Like wise, three nematode species eggs (Ascaris lumbricoides, Trichuris trichiura and Ancyclostoma duodenale) were isolated from the gut and surface of flies. Ascaris lumbricoides occurred more in and on all the flies Chrysomya megacephala recorded the highest prevalence of all the helminth eggs present. On gut content, Chrysomya megacephala recorded the highest number of the different helminth eggs isolated. Interestingly there was no correlation between the occurrence of the helminth eggs species and the three cyclorrhaphan flies identified.
  C.M.U. Ajero , B.E.B. Nwoke , N.J.C. Okolie , H.U. Nwanjo , G. Oze , M.C. Okafor , D. Nwosu , B. Anyaehie and G.C. Uloneme
  In a study to determine the prevalence and intensity of Bancroftian Filariasis (BF) in the Niger Delta area of Eastern Nigeria, 3,400 people in 34 villages were examined. Four hundred and twenty one (12.38%) subjects had Wuchereria bancrofti microfilarIae in their blood. There was a significant difference in the prevalence based on the villages sampled (p< 0.05). More males (15.0%) were infected than females (9.10%) with the female prevalence significantly lower in most of the villages (p< 0.05). The prevalence was age dependent with a progressive rise and decline after 59 years. The intensity of the microfilariae among infected subjects showed a generally low microfilarial count with a mean microfilariae load of 5.5.
 
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