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by
C.C. Yin |
Total Records (
2 ) for
C.C. Yin |
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M.J. Xu
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Y. He
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R. Liang
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D.H. Zhou
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R.Q. Lin
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C.C. Yin
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X.H. He
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M. Liang
and
X.Q. Zhu
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The present investigation aimed to examine the prevalence of Chlamydia infection in pigs in Guangdong Province, Southern China. Between March 2008 and May 2009, a total of 1,017 serum samples were collected from 15 intensive farms, which are distributed in 12 administrative cities of Guangdong Province and assayed for Chlamydia antibodies by Indirect Hemagglutination Assay (IHA). The results showed that almost all of the investigated farms showed seroprevalence (93.33%, 14/15). The average seroprevalence of pigs with Chlamydia antibodies was 30.78% (ranged between 0-88%) with breeding boars having the highest prevalence (63.38%, 45/71), which was followed by breeding sows (41.10%, 60/146) and fattening pigs (36.25%, 29/80). These results indicated that prevalence of Chlamydia infection in pigs from intensive farms in Southern China is high, therefore integrated and improved control strategies and measures should be implemented to prevent and control Chlamydia infection in pigs. |
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G.H. Peng
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Z.G. Yuan
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D.H. Zhou
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X.H. He
,
C. Yan
,
C.C. Yin
,
Y. He
,
R.Q. Lin
,
H.Q. Song
and
X.Q. Zhu
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Toxoplasma gondii infects nearly one third of the total population of the world, as well as warm blooded animals causing serious public health problems and economic losses in the world. Micronemes plays a key role in the invasion process of T. gondii which are used for host cell recognition, binding and motility. In this research, the researchers examined sequence variation in the microneme protein 4 (MIC4) gene sequences of 12 T. gondii isolates and reference strains from different hosts and geographical locations, then constructed the DNA vaccine expressing MIC 4 of T. gondii evaluated its immune response induced in Kunming mice. The results demonstrated that sequence variation in MIC 4 among different T. gondii isolates was low, which is a useful feature as a vaccine candidate. Immunization of mice with pVAX-MIC4 induced strong immune responses in mice as shown by significant lymphocyte proliferation, cytokine production and antibody responses as well as increased survival time of the immunized mice after challenge with tachyzoites of the virulent T. gondii RH strain, demonstrating that T. gondii MIC4 is a potential vaccine candidate against toxoplasmosis. |
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