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Articles by A.H. Gilani
Total Records ( 6 ) for A.H. Gilani
  Sabah B. Zaidi , N. Abbas , A.H. Gilani , M.T. Javed , S. Bukhari and A. Habib
  The study was conducted on 80 male children, divided into three age groups (5-7, 8-10 and 11-12 years). These children were graded into five grades of malnutrition including normal following the criteria of Jelliffe (Alleyne et al., 1978). The results revealed 47.22 per cent normal children while 16.66, 22.22, 11.11 and 2.77 per cent were suffering from Ist, 2nd, 3rd and 4th degree of malnutrition, respectively. Overall means of children categorized in various degrees of malnutrition showed non-significant difference in haemoglobin, RBC, PCV and erythrocytic indices. However, RBC, Hb and PCV values were less in children graded in 4th degree of malnutrition. Hb showed significantly lower (P<0.05) levels in children graded into 3rd than first degree of malnutrition of 8-10 years. However, RBC count was significantly higher (P<0.05) in 3rd than 2nd degree of malnutrition in children of 11-12 years, while PCV was relatively higher in the same subjects of this age group. In overall, 45 per cent of children had less than normal haemoglobin, RBC or both. Out of these, 19.44 per cent showed normocytic hypochromic, 30.55 showed normocytic normochromic, 8.33 microcytic hypochromic, 13.88 microcytic normochromic, 13.88 macrocytic hypochromic and 13.88 per cent showed macrocytic normochromic anaemia. Serum total proteins showed non-significant difference in children graded in various degrees of malnutrition, however, the values in normal subjects were relatively lower than those graded into various degrees of malnutrition.
  Amna Habib , N. Bhatti , A.H. Gilani , M. A. Khan , M. T. Javed and S.B. Zaidi
  Study on 50 pregnant women in Allied Hospital, Faisalabad revealed non significant difference in T4 and TSH levels between women of 2nd and 3rd trimester. Similarly, T4 and TSH levels showed no statistical difference between those women used multivitamins and iodine supplements and those did not used. The correlation between T4 and TSH was higher and negative in women having normal body weight to their height and those did not used multivitamins tablets. However, a positive correlation between T4 and TSH was observed in women those used iodine and negative in women those did not used iodine.
  K.H. Janbaz and A.H. Gilani
  Menthol, a terpenoid from Mentha piperita was investigated for its possible protective effect against paracetamol and CCl4-induced hepatic damage. Paracetamol produced 100% mortality at the dose of 1 g kg -1 in mice while pre-treatment of animals with menthol (50 mg kg -1) reduced the death rate to 40%. Oral administration of paracetamol (640 mg kg -1) produced liver damage in rats as manifested by the rise in serum enzyme levels of alkaline phosphatase (ALP) and transaminase (AST and ALT). Pre-treatment of rats with menthol prevented the paracetamol-induced rise in serum enzymes. The hepatotoxic dose of CCl4 (1.5 ml kg -1; orally) also raised the serum ALP, AST and ALT levels. The same dose of menthol was able to prevent the CCl4-induced rise in serum enzymes and prolongation in pentobarbital sleeping time. In conclusion menthol possesses hepatoprotective activity, demanding further scientific evaluations to validate its future role in hepato-biliary complications.
  K.H. Janbaz , S.A. Saeed and A.H. Gilani
  The hepatoprotective activity of thymol, a terpenoid from essential oils of plant origin was investigated against paracetamol and CCl4-induced hepatic damage. The results showed that paracetamol produced 100% mortality at the dose of 1 g kg 1 in mice while pre-treatment of animals with thymol (150 mg kg-1) reduced the death rate to 30%. Oral administration of paracetamol (640 mg kg-1) produced liver damage in rats as manifested by the rise in serum enzyme levels of alkaline phosphatase (ALP) and transaminases (AST and ALT). Pre-treatment of rats with thymol (150 mg kg-1) prevented the paracetamol-induced rise in serum enzymes. The hepatotoxic dose of CCl4 (1.5 ml kg-1; orally) also raised the serum ALP, AST and ALT levels. The same dose of thymol (150 mg kg-1) was able to prevent the CCl4-induced rise in serum enzymes. The results indicated that thymol also prevented the CCl4-induced prolongation in pentobarbital sleeping time confirming hepatoprotectivity. It was concluded that thymol possesses anti-hepatotoxic activity.
  S.A. Saeed , H. Rasheed , S. Kumar , T.M. Ali , M.U. Butt , R.Dhangana , A. Jafri , S. Zehra and A.H. Gilani
  This study was conducted to examine the mechanism(s) of synergistic interaction of platelet-activating factor (PAF) and arachidonic acid (AA) in platelet aggregation. We found that the synergism in platelet aggregation mediated by subthershold concentration of PAF (5-40 nM) and AA (0.1-0.2mM) was inhibited by PAF receptor blocker (WEB 2086, IC50= 0.6 µM) showing that the effect is receptor mediated. To examine the role of the downstream signaling pathways, we found that such an interaction was inhibited by calcium channel blockers, diltiazem (IC50= 15 µM) and verapamil (IC50 = 20 µM), as well as by low concentrations of phospholipase C (PLC) inhibitor (U73122; IC50 = 6 µM) and MAP kinase inhibitor, PD 98059 (IC50= 3.5 µM). Inhibitor of AA-cyclooxygenase (flurbiprofen: IC50 = 3 µM) also inhibited PAF and AA induced aggregation showing the involvement of COX pathway. On the other hand, herbimycin A, a specific inhibitor of tyrosine light chain kinase (TLCK) and SNAP, a nitric oxide (NO) donor also inhibited PAF and AA-induced aggregation with IC50 values of 15 and 1.7 µM respectively. However, the inhibitor of protein kinase C (chelerythrine; 20 µM)) had no effect on aggregation induced by PAF and AA. These data suggest that the synergism between PAF and AA in platelet aggregation involves activation of PLC, COX, MAP kinase, TLCK and NO signaling pathways.
  S.I.H. Taqvi , M.N. Ghayur , A.H. Gilani , M.T. Aftab and Z.S. Saify
  The smooth muscle relaxant and cardiovascular suppressant activities of a newly synthesized piperidine derivative: (1-[4´-methylphenacyl]-4-acetyl-4-phenylpiperidinium bromide) were studied in isolated tissue preparations. The test compound exhibited dose-dependent relaxant effect on the spontaneous and K+ (75 mM)-induced contractions of isolated rabbit jejunum with respective EC50 values of 0.056 mM (0.011-0.289, 95% CI) and 0.052 mM (0.004-0.769). The Ca++ channel blocking (CCB) activity was confirmed when the test compound (0.005-0.020 mM) shifted the Ca++ dose-response curves to the right, similar to that produced by verapamil (0.3-1.0 μM), a standard CCB. In the isolated rabbit aorta, the test compound showed a dose-dependent vasodilator effect on norepinephrine (1 μM) or K+ (75 mM)-induced contractions with an EC50 value of 0.016 mM (0.005-0.048). When tested in Langendorff perfused rabbit heart preparation, it exhibited a negative chronotropic effect in atria and ventricles with respective EC50 values of 0.79 mM (0.45-2.05) and 0.63 mM (0.32-1.52) and also a negative inotropic effect in atria and ventricles with respective EC50 values of 0.98 mM (0.30-3.19) and 8.98 mM (5.98-13.50). The results showed that inhibitory effects of the piperidine derivative on intestinal and cardiovascular preparations are mediated possibly via blockage of voltage and receptor-operated Ca++ channels.
 
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