Abstract: During the last 10 years, several scientists around the world investigate the effect of growth factors on the reconstruction of mandibular and maxillary bone. The aim of these studies is the use of safer materials and techniques that could promise a good result. Platelet in Platelet-Rich Plasma (PRP) contain a very big amount of growth factors as PDGF, TGF- , VEGF and IGF. The aim of this study, is the review of the results of several researches that are based on the potential of PRP to enhance bone healing at humans and animals, mainly in combination with graft materials. In this study results of the most important studies, based on the use of PRP, are exposed and analyzed. These findings are controversial. Some researchers insist on the positive effect of PRP on bone augmentation, while others do not support the use of PRP as a technique with certain advantages. It is important for researchers to consecrate some certain protocols about studies transaction, homogeneity of the samples, PRP preparation, PRP use and the evaluation of the results. In addition to the above mentioned, physical, biological and biochemical properties of growth factors must be identified to offer the opportunity of good and long-lasting treatment. Overall, PRP application is very promising, especially for the treatment of no totally healthy patients whose condition requires fast ant safe procedures of bone and other tissue healing.