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Abstract: Pulmonary Tuberculosis (PTB) is a common disease in developing countries and efforts have been made to diagnose patients presenting complex hematological and biochemical picture. Hematological abnormalities have been associated with tuberculosis and response to drug therapy often showed varied resistance. However, changes in response to therapy have not fully been determined in PTB patients living in the developing countries. In PTB patients rise in hemogloin and hematocrit levels are used as markers reflecting response to treatment. Furthermore, decrease in platelet count and in white cell count and reduction in Erythrocyte Sedimentation Rate (ESR) were regarded as good indicatiors to obverve drug responce and disease control. During current study mild anemia was frequently observed in PTB patients. Several reports suggested leucocytosis with neutrophilia. Platelet count and erythrocyte sedimentation rate were elevated in PTB which is well influenced and corrected by using different combinations of antituberculosis drugs. Although several investigations have been done on adult male and female PTB parients in Saudi Arabia, however, there is no comprehenssive report available on the significance of different haematological parameters in pretreatment and post-treatment PTB patients. Current study was designed to investigate hematological changes both in adult male and female Saudi PTB patients. All the parameters at the time of diagnosis and 6 weeks post-treatment were studied and the results are present in current communication.