Abstract: The ethanol extract of leaves of Hoya parasitica was tested for its phytochemical groups, antibacterial and antinociceptive activities. The ethanol extract showed the presence of flavonoids, reducing sugars, tannins, gums and saponins. The extract showed moderate antibacterial activity against both gram-positive and gram-negative bacteria. It also produced significant (p<0.01) writhing inhibition in Swiss albino mice at oral dose of 500 mg kg^-1 body weight comparable to the standard drug diclofenac sodium.