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Abstract: Efforts in this study were directed at comparing changes in Packed Cell Volume (PCV) in the cause of treatment of severe malaria patients with artemether and quinine in Ikenne Local Government area of Ogun State, Southwest, Nigeria. Thirty two patients in the study were randomly assigned to receive either artemether or quinine under medical supervision. 16 patients were allocated into two treatment groups. Patients in the quinine group received quinine 10 mg kg-1 in 5% dextrose-saline infusion intravenously at 8 h intervals but changed to oral quinine ( 10 mg kg-1 b.w; 8 h intervals) for 7 days . The patients in the artemether group received 1.6 mg kg-1 artemether twice at day 0 and then 1.6 mg kg-1 daily for the next four days through deep intramuscular route. The patients were then followed up for 14 days. The results this study showed that the PCV of the patients was 25.9% (range of 14-41%) at day 0. The mean PCV of the patients was 26.25% and 25.56% following quinine and artemether treatments, respectively. The mean PCV at day 14 was 34.5 and 38.2%, respectively for quinine and artemether. The results from this study indicate that artemether relative to quinine has a faster and sustained recovery from malaria induced anaemia.