Citation Index is committed to provide an authoritative, trusted
and significant information by the coverage of the most important
and influential journals to meet the needs of the global scientific
Abstract: Listeria monocytogenes is a facultative, intracellular, gram positive bacterium that is responsible for sever infections, including prenatal infections, septicemia and meningoencephalitis in humans and a wide variety of animal species. In this study, efficacies of co-trimazine in an immunosuppressed mouse model of listeriosis was compared with co-trimoxazole. After treatment with co-trimazine (400 mg kg-1 of sulphadiazine and 80 mg kg-1 of trimethoprim) every 12 h for 3 days, Listeria monocytogenes could not recovered from the livers of the mice. In contrast, after treatment with co-trimoxazole (400 mg kg-1 sulphamethoxazole and 80 mg of trimethoprim) every 12 h for 3 days, a mean of 3 x 103 colony-forming unit (CFU) was recovered from the livers of mice. Results showed that antibacterial efficacy of co-trimazine was more than co-trimoxazole in experimental infections with Listeria monocytogenes.