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Abstract: Sero-monitoring of peste des petits ruminants (PPR) in 750 goats and 500 cattle were studied 15 different districts of Bangladesh. This study was undertaken with a view to evaluate the serum antibody level against PPR virus in goats, determination of level of PPR antibodies in large ruminants, and finally to determine the risk of goat population to PPR based on age. The experiment was conducted at the Virology Laboratory of Bangladesh Livestock Research Institute (BLRI), Savar, Dhaka. In most districts, the antibody level against PPR Virus (PPRV) in goats varied between 4-98% with an average 49.33% and only 3-10% was found positive against rinderpest in C-ELISA The highest level of antibody against PPRV was found in Hill tracts (98%) and the lowest in Pabna (4%). In terms of Rinderpest (RP) antibody as being detected by C-ELISA, it was observed that the sera collected from Jessore, Faridpur and Tangail showed very low levels of antibody, which varied between 3-10%. The results from the examination of cattle sera from four selected areas of Bangladesh showed that antibody level against PPRV varied from 17.64-36.84% with an average 24.67% and 0-26.31% found positive against RP in C-ELISA. So the present findings are the indication of future problem in proper evaluation of rinderpest vaccination programme in Bangladesh particularly with low sero-conversion in vaccinating herds as they have already been sensitized by PPRV.