Abstract: This study was carried out to study the characteristics of Caprine anaphylaxis with emphasis on clinical features observed during pre and post Sensitization. Six goats of mixed breed were sensitized to the repeated injections of horse serum. During sensitization common clinical signs observed after second and third antigenic injections were frequent urination, defecation, cough, nasal secretion, irregular respiration and heart beat, dullness and depression confirms the success of sensitization. After a latent period of three weeks, all animals were challenged to horse plasma intravenously. Post challenge clinical signs included respiratory distress characterized by a multifold increase in frequency and thoracolumbar irregular and jerky respiration, nasal secretion, severe coughs, shivering, paddling and kicking. Auscultation revealed moist rales over the lung area. Animals were dull, depressed and unwilling to move. The clinical signs observed during anaphylaxis indicate that the lung may be the major shock organ of anaphylaxis in goats. The results of this study will help in the establishment of appropriate and specific therapy for Type-I hypersensitivity reactions (Anaphylactic- shock) in goat specie.