Abstract: A comparative pharmacokinetic study of chloramphenicol (25 mg kg^-1 intravenous) by chemical assay method and its combination with sulphamethazine (33 mg kg^-1) in Sokoto red goats has revealed that the mean peak plasma concentrations at 0.08 h post drug administration were not significantly different. However, various pharmacokinetic parameters were significantly altered (p<0.05) after the combination therapy; the total body clearance (Cl) and elimination constant (β) were significantly higher whereas the half life of elimination (t½ β) and the distribution rate constant were significantly lower. These changes observed in this study could be an indication that, the combination therapy may require a reduced chloramphenicol dose without necessarily minimising the efficiency of the drug and this may also possibly reduce the risk of dose-related toxicity.