Citation Index is committed to provide an authoritative, trusted
and significant information by the coverage of the most important
and influential journals to meet the needs of the global scientific
Abstract: A comparative pharmacokinetic study of chloramphenicol (25 mg kg-1 intravenous) by chemical assay method and its combination with sulphamethazine (33 mg kg-1) in Sokoto red goats has revealed that the mean peak plasma concentrations at 0.08 h post drug administration were not significantly different. However, various pharmacokinetic parameters were significantly altered (p<0.05) after the combination therapy; the total body clearance (Cl) and elimination constant (β) were significantly higher whereas the half life of elimination (t½ β) and the distribution rate constant were significantly lower. These changes observed in this study could be an indication that, the combination therapy may require a reduced chloramphenicol dose without necessarily minimising the efficiency of the drug and this may also possibly reduce the risk of dose-related toxicity.