Abstract:
The research was conducted to investigate the in
vitro antimicrobial and cytotoxic activities of leaves and flowers
extract extracted from Lippia alba. Disc diffusion technique was
used for in vitro antibacterial and antifungal screening. Zones
of inhibition were observed in disc diffusion for antibacterial screening
against 4 Gram-positive pathogenic and 6 Gram-negative pathogenic bacteria.
Among crude extracts chloroform extract showed good activity against all
test organisms. A Large zone of inhibition was observed (18 mm) against
Vibrio parahaemolyticus. In antifungal screening, the compound
showed mild to moderate zones of inhibition against four tested organisms.
A Large zone of inhibition was observed against Aspergillus niger
(13 mm). Cytotoxic activities of crude extracts were determined using
Brine shrimp lethality Bioassay and LC 50 values of standard
Vincristin sulphate as positive control, n-hexane and crude ethanol extracts
were found to be 5, 15 and 20 μg mL-1, respectively.
N. Ara, M.H. Nur, M.S. Amran, M.I.I. Wahid and M. Ahmed, 2009. In vitro Antimicrobial and Cytotoxic Activities of Leaves
and Flowers Extracts from Lippia alba. Pakistan Journal of Biological Sciences, 12: 87-90.
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