Preventive Effect of Bridelia ferruginea Against High-fructose Diet Induced Glucose Intolerance, Oxidative Stress and Hyperlipidemia in Male Wistar Rats
Abstract:
The root of B. ferruginea is traditionnally used as a treatment for type 2 diabetes. The present study was investigated to evaluate the preventive effect of B. ferruginea on some markers of metabolic syndrome in type 2 diabetes (hyperlipidemia, glucose intolerance, obesity and oxidative stress) induced by high fructose and fat diet in male Wistar rat. The rats received fructose diet (10 mL kg-1 per day) during 42 days; at the 15th day to the 42nd day 15 min before, they received distilled water for high fructose diet group, metformine 100 mg kg-1 per day or extract 125 and 250 mg kg-1 per day for treatment group. The control group received only distilled water during the experiment. After 6 weeks of experiment, fasting blood glucose, liver MDA level, body weight gain, intra abdominal grease, serum triglyceride (TG) and total cholesterol levels in treated groups were significant lower than that of high- fructose diet group. However, rats in treated group were not found to have a significant change of blood HDL Cholesterol level. In the oral glucose tolerance test, rats in treated group had a significantly reduced blood glucose concentration during 180 min after glucose load, indicating that B. ferruginea root improved glucose tolerance. In conclusion, our plant can prevent metabolic syndrome induced by high fructose diet.
B. Bakoma, K. Eklu-Gadegkeku, A. Agbonon, K. Aklikokou, E. Bassene and M. Gbeassor , 2011. Preventive Effect of Bridelia ferruginea Against High-fructose Diet Induced Glucose Intolerance, Oxidative Stress and Hyperlipidemia in Male Wistar Rats. Journal of Pharmacology and Toxicology, 6: 249-257.
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