Immunol, a polyherbal formulation was evaluated for its safety and effect on the immune system of rats. The rats were administered a single oral dose of 20 mL kg-1 b.wt. while others were given repeated doses of 1, 5 and 10 mL kg-1 b.wt., orally for 28 days. Immunol treatment did not elicit any abnormalities on the body weight gain, food consumption, neurological assessment, hematology and clinical chemistry parameters, organ weights, gross organ pathology and histopathology and humoral immunity, but it enhanced the cell mediated immunity. It was concluded that Immunol was safe at single oral dose of 20 mL kg-1 b.wt. and repeated dose of 10 mL kg-1 b.wt. in rats for 28 days.
S.M. Sulaiman, Geetha Rajashekhar, P.J. Prakash, D.S. Singh and C. Saleem, 2010. Evaluation of Safety and Immunotoxicity of Immunol, A Polyherbal Formulation in Rats. Journal of Pharmacology and Toxicology, 5: 262-274.