Lecaniodiscus cupanioides Planks. ExBth (Sapindaceae) is widely used in Nigerian folk medicine for the treatment of inflammatory conditions, hepatomegaly and bacterial infections. This study investigated the antioxidant and antibacterial activity of the methanolic extract of the leaves to justify its use in traditional medicine. Extract exhibited strong DPPH and ABTS radical scavenging activity greater than BHT and comparable to ascorbic acid. 0.1 mg mL-1 extract inhibited DPPH and ABTS radicals up to 99.4 and 98.5%, respectively. Multiple antioxidant activity of extract was evident with moderate reducing power. TAE (37.678±1.66 mg g1 dry extract) was higher than that reported in many other plant extracts. Flavonoid and proanthocyanidin contents were 4.142±0.06 and 2.548±0.32 mg g-1, respectively. Strong correlation recorded; ABTS/TAE (R2 = 0.89), DPPH/TAE (R2 = 0.90). Antimicrobial activity was highest on gram +ve organisms B. cereus, S. aureus, M. kristine and S. pyrogens (MIC value < 1.0 mg mL-1). Gram-ve S. pooni and P. aeruginosa (MIC value = 2.0 mg mL-1). Results attributed the antioxidant potential of L. cupanioides leaf extract to its strong proton donating ability and justified its use for the treatment of bacterial infections in ethnomedicine.
04 June, 2009
Ukam, Ngozi Uchechi: this paper is very intersting to me as my phD
desertation is on "the potentials of some wild and/leaves of trees consumed in Baise L.G.A of Cross River State, Nigeria".I would like some of these publications sent to my e-mail box.