Abstract:
Combination drug interaction
between sodium phenobarbitone and halofantrine was studied biochemically
in weaning rats. Groups were made according to their body weights. All
the rats were sacrificed after 4 days of drug administration and the
liver homogenates and blood prepared for biochemical and haematological
investigations of cytotoxicity. Results showed that total protein contents,
monooxygenase, acid phosphatase and alkaline phosphatase activities
in the liver increased with increase in drug administered for all the
tests compared with the drug free controls. In the haematological analysis,
there was increase down the column with increase in drug for RBC, PCV
and Hb while the reverse was the case for WBC (total and differential)
compared with the controls. This would suggest that phenobarbitone had
an overwhelming sparing effect on the depletion of the haematological
parameters and induced their synthesis and lymphocytic maturation but
inhibited eosinophil production. The result indicated that phenobarbitone
affected the cytotoxic and haematological effects of halofantrine, an
antimalarial drug.
H.C.C. Maduka , A. Salihu and V.A. Onwuliri , 2003. Biochemical Evaluation of Combination Drug Interaction Between Phenobarbitone and Halofantrine in Weaning Rats. Journal of Biological Sciences, 3: 711-717.
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