Venomous snakebite has been a major cause of mortality and morbidity across the Asian, African and Latin American countries. Lack of medical infrastructure, ineffectiveness of conventional antivenin and malpractice by the local quacks worsen the scenario. The present review deals with the pharmacological investigations performed in different botanicals for antiophidian principles. It also includes a list of certain traditionally used medicinal plants with potential anti snake venom efficacy. The authors have compiled a number of plants active in vitro and/or in vivo against the toxicity of various snake venoms causing an array of biological symptoms. This review also compiles the information regarding the possible use of plant derived natural product based antivenins in order to find cheap and effective alternative source of snake venom antidote especially for the third world tropical countries. From a variety of literature sources the data has been collected mentioning the plants alphabetically and their respective families with notes on plant parts and solvent system used, in vitro and in vivo analyses, activity against the toxicity and biological symptoms related to poisonous snakebite, dose dependence, experimental models, efficacy of the isolated compound(s), ethnobotanical and clinical relevance etc.