Abstract:
This study is conducted to investigate the possible
hepatoprotective action of Moringa oleifera Lam. (MO), a high value
medicinal plant against a single high dose of APAP induced hepatotoxicity.
Male Sprague Dawley rats were dosed with APAP (3000 mg kg-1
body weight; p.o.) to induce hepatocellular damage. In rats that were
pretreated with MO (200 and 800 mg kg-1; p.o.) for 14 days
prior to APAP treatment, there was a reduction of liver enzymes (ALT,
AST and ALP) and also the restoration of glutathione level. The biochemical
results showed parallel finding with the histopathological analysis in
which liver sections obtained from rats pretreated with MO, the damage
was blocked. Intriguingly, MO alone has significantly elevated the level
glutathione compared to the control group. The findings has suggested
that Moringa oleifera Lam. is a promising product in protecting
the liver against APAP induced liver injury via the restoration and elevation
of glutathione level in the liver.
S. Fakurazi, U. Nanthini and I. Hairuszah, 2008. Hepatoprotective and Antioxidant Action of Moringa oleifera Lam.Against Acetaminophen Induced Hepatotoxicity in Rats. International Journal of Pharmacology, 4: 270-275.
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