The antitumour activity of ethanol extract of Indigofera trita L.f (EIT) was evaluated against Ehrlich Ascites Carcinoma (EAC) tumour model in Swiss albino mice on dose dependent manner. The activity was assessed using survival time, average increase in body weight, hematological parameters and solid tumour volume. Oral administration of EIT (200 and 400 mg kg-1) increased the survival time and decreased the average body weight of the tumour bearing mice. After 14 days of inoculation, EIT was able to reverse the changes in the hematological parameters, protein and PCV consequent to tumour inoculation. Oral administration of EIT was effective in reducing solid tumour mass development induced by EAC cells. The results indicate that EIT possess significant antitumour activity on dose dependent manner.
Raju Senthil Kumar, Balasundaram Jayakar and Balasubramanian Rajkapoor, 2007. Antitumour Activity of Indigofera trita on Ehrlich Ascites Carcinoma Induced Mice. International Journal of Cancer Research, 3: 180-185.