Abstract:
Benzopyran derivates were efficiently synthesized by the reaction of acetophenone and acetic anhydride in the presence of base for excellent yield. The methodology comprise of four main steps friedel craft acylation proceeded by aldol condensation, methoxylation, reduction and esterification. Substituted phenol was first acylated with acetic acid in presence of lewis acid to substituted acetophenone which was smoothly converted to benzopyran, by condensing with substituted ketones in presence of a base such as amberlite though the aldol condensation reaction. H1-NMR, IR, MASS septra analysis conclusively confirmed the structure of 2,2-Dimethyl-7-hydroxy-3,4-dihydro-2H-1-benzopyran-4-one, 2,2-Dimethyl-3,4-dihydro-7-methoxy-2H-1-benzopyran-4-one,2,2-dimethyl-7-methoxy-6-nitro-3,4-dihydro-2H-1-benzopyran-4-one.
N.S. Gill, A. Jain and T. Taneja, 2012. The Synthesis of Benzopyran Analogues with Variation at C-2, C-4 and C-7 Positions. Current Research in Chemistry, 4: 18-25.
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