Due to the notable medicinal value of Limoniastrum feei, it was considered of interest to carry out phytochemical and antimicrobial investigations of this specie. The antimicrobial activity of several crude extracts of leaves, stem and Twig parts of Limoniastrum feei was evaluated by disc diffusion method. Crude extract of this medicinal plant tested against fungi (C. albican and Saccharomyce cerevisiae) and bacteria (E. coli, S. aureus, P. aeruginosa, K. pneumoniae and E. fecalis). A broad spectrum of antimicrobial activity was exhibited by the methanol extracts of leaves, stem and Twig of Limoniastrum feei. The results were comparable to standard antifungal drug at equivalent concentration. The methanol extract exhibited higher antibacterial activity than water and acetone extract from leaves. C. albican showed resistance to all extract of stem. Based on these results, it can be concluded that this plant has antimicrobial activity, which is as patent as standard antimicrobial drugs against certain microorganisms.