Abstract:
Free radicals are causative factors for aminoglycoside
induced renal toxicity. The aim of present study was to evaluate effect
of fixed dose combination of cefepime+amikacin (Potentox) as well as ceftazidime+tobramycin
(Tobracef) antibiotics on antioxidant enzymes (Super oxide dismutase,
Catalase and Glutathione reductase) along with (free radical mediated
damage) malonaldialdehyde levels and extracellular antioxidant enzymes
(creatinine, total bilirubin and uric acid enzymes ) in kidney tissue
of Mus musculus mice. Present findings showed that the activities
of the antioxidant enzymes were significantly lowered along with increase
in MDA (malonaldialdehyde) levels and extracellular antioxidants after
single treatment of aminoglycosides (amikacin and tobramycin) as compared
to control group. A significant improvement in antioxidant enzymes along
with significant decrease in creatinine, total bilirubin, uric acid and
malonaldialdehyde (MDA) levels were observed in fixed dose combination
of cefepime plus amikacin as well as ceftazidime+tobramycin treated groups
compared to amikacin and tobramycin alone treated group. These results
indicate that a fixed dose combination of cephalosporins with aminoglycosides
using chemical vector mediated technology acts as an antioxidant and prevents
nephrotoxicity induced by aminoglycosides.
V.K. Dwivedi, M. Chaudhary, A. Soni and S.M. Shrivastava, 2009. Nephrotoxicity Reduction by Fixed Dose Combination of Cephalosporins and Aminoglycosides in Mus musculus Mice. Asian Journal of Biochemistry, 4: 13-21.
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