The present study was undertaken to elucidate the mechanism responsible for ameliorating effect of asiaticoside rich Centella asiatica leaf extract (CAE) on fatigue. CAE at 10 mg kg-1 b.wt. was administered orally to rats for 2 weeks and subjected to weight-loaded forced swim test (WFST) every alternative day for a period of three weeks to evaluate physical fatigue. CAE administrated rats prolonged the swimming time for exhaustion almost two fold compared to the control. Moreover, WFST also reduced the levels of glycogen content in muscle and liver tissues and activities of superoxide dismutase and catalase in liver and brain tissues. These effects were reverted back with the administration of CAE and therefore it is concluded that C. asiatica extract ameliorates the various impairments associated with physical fatigue in enhancing the physical endurance capacity.
T. Anand, G. Phani Kumar, N. Ilaiyaraja, Farhath Khanum and A.S. Bawa, 2012. Effect of Asiaticoside Rich Extract from Centella asiatica (L.) Urb. on Physical Fatigue Induced by Weight-loaded Forced Swim Test. Asian Journal of Animal and Veterinary Advances, 7: 832-841.