Subscribe Now Subscribe Today
Science Alert Home Journals at Science Alert For Authors For Subscribers Contact Us
   
Research Journal of Medicinal Plants
  Year: 2015 | Volume: 9 | Issue: 2 | Page No.: 60-71
DOI: 10.3923/rjmp.2015.60.71
Sub-Acute Evaluation of Extract of Syzygium malaccense in Albino Rats
Abiodun Humphrey Adebayo, Oyinlade Cecilia Ogundare and Oluwatobi Samuel Adegbite

Abstract:
The study was aimed at investigating the sub-acute evaluation of the extract of Syzygium malaccense in albino rats. Five groups of eight rats per group were orally administered with graded 50, 100, 250 and 500 mg kg-1 b.wt. doses of the extract for 28 days. Blood samples of the sacrificed rats were collected for biochemical and haematological studies while liver and kidney tissues were used for histopathological assessment. The results showed an LD50 of 1224.75 mg kg-1 b.wt. with no significant (p>0.05) changes in weight of organs tested. Biochemical parameters such as AST, ALP, protein and albumin levels in all the treated animals did not change significantly, however, there was significant (p<0.05) change in the activity of ALT as well as haematological parameters such as RBC, WBC, HGB, platelet counts, MCV and MCH when compared with the control group. The results from histopathology showed an inflammation of the liver cells at doses beyond 100 mg kg-1 b.wt. but there was no significant damage to the kidney tissue. It may be concluded that the extract of S. malaccense possesses the tendency of affecting the haematopoietic elements and may also alter the structural integrity of the liver tissue if ingested at higher doses.
 [Fulltext PDF]   [Fulltext HTML]   [XML: Abstract + References]   [References]   [View Citation]  [Report Citation]
 RELATED ARTICLES:
  •    Nutritional Qualities of Three Medicinal Plant Parts (Xylopia aethiopica, Blighia sapida and Parinari polyandra) commonly used by Pregnant Women in the Western Part ofNigeria
  •    The Effects of Ethanolic Leaf Extract of Commiphora africana (Buseraceae) on Lipid Profile in Rats
  •    The Effects of Ethanolic Leaf Extract of Commiphora africana (Burseraceae) on Rat Liver and Kidney Functions
  •    Acute and Sub-chronic Toxicity Studies of Crude Aqueous Extract of Albizzia chevalieri Harms (Leguminosae)
How to cite this article:

Abiodun Humphrey Adebayo, Oyinlade Cecilia Ogundare and Oluwatobi Samuel Adegbite, 2015. Sub-Acute Evaluation of Extract of Syzygium malaccense in Albino Rats. Research Journal of Medicinal Plants, 9: 60-71.

DOI: 10.3923/rjmp.2015.60.71

URL: http://scialert.net/abstract/?doi=rjmp.2015.60.71

 
COMMENT ON THIS PAPER
.
 
 
 
 

 

 
 
 
 
 
 
 
 
 

 
 
 
 
 
 

                 home       |       journals        |       for authors       |       for subscribers       |       asci
          © Science Alert. All Rights Reserved