Several studies suggest that there was relationships between energy drink consumption and problem behaviors among adolescents and adults as it increase lipolysis glycogenolysis and catecholamine secretion. This study aimed to find out the potential effects of high energy drinks recommended intake and toxic dose on normal and hyperglycemic rats. Thirty-six (36) male adult Sprague-Dawley rats weighting 145±5.3 g each were used in this investigation. Non-diabetic rats [control-ve 6 rats feed on basal diet only and 12 Normal Rats (NR) divided into two groups consumed basal diet with 1 and 2 ml of High Energy Drink (HED) by gastric tube], while Diabetic Rats (DR) control+ve 6 rats received basal diet only and 12 rats divided into two groups consumed basal diet with 1 and 2 ml of HED after injected with alloxan for inducing diabetes mellitus. Body Weight Gain (BWG) and food intake were recorded weekly for 6 weeks. Blood samples were collected after 12 hours fasting at the end of experiment. Liver was removed and weighted. Blood serum was prepared for measurements of glucose, triglyceride, cholesterol, HDL-c, LDL-c, VLDL-c, AST, ALT and ALP. The BWG of NR groups received 2 ml only and DR groups received 1 and 2 ml of HED by oral injection recorded significant decrease (p<0.001) as compared to the control negative group. Blood glucose level was significantly higher (p<0.001) for DR fed on 1 and 2 ml compared with control (-). Serum AST, ALT and ALP were significantly higher (p<0.01 and p<0.001 resp.) for NR received the two doses of HED compared with normal rats control (-). As for cholesterol, triglycerides and LDLc levels were significantly higher (p<0.01) in the hyperglycemic rats group fed on 2 ml of HED compared with control (-). Also LDLc/HDLc ratio increased gradually when the level of HED increased. Oral injection by HED cause histopathological changes in the liver for NR and DR like atrophy and cell damage also changes in the chemical and morphological structure.