Abstract:
Male and female albino mice were fed on maize (control) and gari (a dried cassava product) based diets for 5 weeks. Liver mitochondrial fractions were assayed for succinate dehydrogenase and Cytochrome C oxidase activities. There was an overall reduction in the activity of the two enzymes studied throughout the experiment. The reduction in activity was pronounced in Cytochrome c oxidase. Kinetic studies of succinate dehydrogenase showed an apparent increase in the Km of the gari fed animals-further supporting that inhibition took place. There was also a reduction in the mitochondrial respiratory control ratio (RCR) for the gari fed mice. The percentage reduction in RCR increased from 4.4% in the 2nd week to about 45% in the 5th week.
E.U. Ezeji, O. Obidua, I.G. Kalu and I.N. Nwachukwu, 2009. Effect of Gari Diet on Marker Enzymes of Mice Liver Mitochondria. Pakistan Journal of Nutrition, 8: 414-418.
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