Johnes disease or Paratuberculosis has emerged as major infectious disease of animals in general and domestic livestock in particular on global basis. There have been major initiatives in developed countries for the control of this incurable malady of animals and human beings alike (inflammatory bowel disease or Crohns disease). Disease has not received similar attention due to inherent complexities of disease, diagnosis and control, in resource poor counties around the world. However, the rich genetic diverstiy of the otherwise low productive animal population offers opportunity for the control of Johnes disease and improve per animal productivity. Present review aims to gather and compile information available on genetics or resistance to Johnes disease and its future exploitation by resource poor countries rich in animal diversity. This review will also help to create awareness and share knowledge and experience on prevalence and opportunities for control of Johnes disease in the livestock population to boost per animal productivity among developing and poor countries of the world. Breeding of animals for disease resistance provides good, safe, effective and cheaper way of controlling Johnes disease in animals, with especial reference to domestic livestock of developing and poor countries. Study will help to establish better understanding of the correlation between host cell factors and resistance to MAP infection which may have ultimately help in the control of Johnes disease in future.
Shoor Vir Singh, Kuldeep Dhama, Kundan Kumar Chaubey, Naveen Kumar, Pravin Kumar Singh, Jagdip Singh Sohal, Saurabh Gupta, Ajay Vir Singh, Amit Kumar Verma, Ruchi Tiwari, Mahima , S. Chakraborty and Rajib Deb, 2013. Impact of Host Genetics on Susceptibility and Resistance to Mycobacterium avium Subspecies Paratuberculosis Infection in Domestic Ruminants. Pakistan Journal of Biological Sciences, 16: 251-266.