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Pakistan Journal of Biological Sciences
  Year: 2010 | Volume: 13 | Issue: 12 | Page No.: 596-603
DOI: 10.3923/pjbs.2010.596.603
Efficacy of Papain-based Wound Cleanser in Promoting Wound Regeneration
S.A.S.H. Ajlia, F.A.A. Majid, A. Suvik, M.A.W. Effendy and H. Serati Nouri

Abstract:
A new invention, papain-based wound cleanser is formulated by incorporating papain, a proteolytic enzyme extracted from Carica papaya into the formulation. This cleanser is invented to simplify the methods in wound management by combining wound cleansing and wound debridement using a single formulation. This study describes the preparation and preclinical study of papain-based wound cleanser in accelerating wound healing. In this study, papain-based wound cleanser was used to treat wound incision on Sprague-Dawley rats while distilled water and Betadine® were used as negative and positive control. Twenty-seven clinically healthy white rats were randomly divided into three groups and treated accordingly until the 21st day post-incision. Wound reduction rates and histological analysis were obtained to asses the healing pattern. Rats treated with papain-based wound cleanser showed a progressive wound healing based on the wound reduction rates and histological analysis when compared with rats treated with distilled water and Betadine®. Better collagen deposition and presence of skin organelles in rats treated with papain-based wound cleanser demonstrated its efficacy in promoting wound healing. In addition to its wound healing effect, papain-based wound cleanser is also integrated with antibacterial properties which make it a complete package for wound management. However, further studies should be carried out to ensure its safety for human usage.
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How to cite this article:

S.A.S.H. Ajlia, F.A.A. Majid, A. Suvik, M.A.W. Effendy and H. Serati Nouri, 2010. Efficacy of Papain-based Wound Cleanser in Promoting Wound Regeneration. Pakistan Journal of Biological Sciences, 13: 596-603.

DOI: 10.3923/pjbs.2010.596.603

URL: http://scialert.net/abstract/?doi=pjbs.2010.596.603

 
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