Various clinical observations and experimental data
from in vitro studies suggest that insulin and sex hormones interact.
The main purpose of the present study was to examine the effects of testosterone
and estradiol on serum insulin in rats. Seven week old male and female
albino (Wistar) rats were used in our study. Testosterone enanthate (50
mg kg-1 day-1) or estradiol valerate (200 μ g
kg-1 day-1) were injected intraperiotenally or subcutaneously
in orchidectomised or ovariectomised rats, respectively. In orchidectomised
rats, serum insulin was decreased compared with control animals (p<0.01),
on the other hand, decreasing of serum insulin was prevented by testosterone
replacement (p<0.001). In ovariectomised rats, serum insulin was also
decreased compared with control group (p<0.01) and decreasing of serum
insulin was prevented by estradiol replacement (p<0.05). Conclusively,
present findings indicated that testosterone or estradiol were serum insulin
enhancer hormones in male or female rats, respectively.
R. Ahmadi and Sh. Oryan, 2008. Effects of Ovariectomy or Orchidectomy and Estradiol Valerate or Testosterone Enanthate Replacement on Serum Insulin in Rats. Pakistan Journal of Biological Sciences, 11: 306-308.