Abstract:
The sub-acute toxicity studies of the compounds 2-hydroxybenzoate-deoxoserine and 2-hydroxybenzoate-deoxo-dehydroxyserine were carried out on Long Evan`s rats using daily administration (30 μg/rat/day) of compounds for 14 consecutive days. The body weight of all rats (control and experimental) were increased after drug administration that was found to be statistically insignificant. No mentionable changes were found in the values of total count of RBC and WBC, differential count of WBC, platelet count, E.S.R and hemoglobin percentage of the drug treated rats in comparison to control rats. Biochemical parameters of blood e.g. SGOT, SGPT, SALP, urea and creatinine of both experimental and control rats were found to increase slightly with respect to the control rats but remained within the normal range.
M.A. Mojid Mondol , 2006. Sub-Acute Toxicity Study of 2-Hydroxybenzoate-deoxoserine and 2-Hydroxbenzoate-deoxo-dehydroxyserine Isolated from Streptomyces Species. Pakistan Journal of Biological Sciences, 9: 1306-1309.
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